目的 制備1,3-二羥基異丙氧基-琥珀酸-8-莪術(shù)醇酯納米混懸劑（Cur-p-NS），并考察其一般特性、載藥量和體外釋放特性。方法 采用超聲–溶劑沉淀法制備Cur-p-NS，考察其粒度大小，多聚分散系數(shù)和Zeta電位。結(jié)果 Cur-p-NS的平均粒徑為162.60±2.12 nm，多分散系數(shù)為0.182±0.002，Zeta電位為-24.60±8.97 mV，平均載藥量為0.942 mg/mg，累積釋放率可達到77%。結(jié)論 Cur-p-NS制備工藝簡單和效果好，具有持續(xù)釋放的特性。

Objective To prepare 1, 3-dihydroxyisopropoxy-succinic acid-8-curcumol ester nanosuspensions (Cur-p-NS) and study their general characteristics, drug loading, and drug release characteristics in vitro. Methods Cur-p-NS was prepared by ultrasonic- solvent precipitation. And the particle size, polydispersion index, and Zeta potential of the nanosuspension were studied. Results The particle size, polydispersion index, Zeta potential,the drug-loading content, and the cumulative release rate of the nanosuspension were 162.60 ± 2.12 nm, 0.182 ± 0.002, -24.60 ± 8.97 mV, 0.942 mg/mg, and 77%, respectively. Conclusion Cur-p-NS has simple preparation and good effect, which has characteristic of sustained release.

國家自然科學(xué)基金資助項目（81302656）；中國醫(yī)學(xué)科學(xué)院醫(yī)學(xué)與健康科技創(chuàng)新工程經(jīng)費資助項目（2016-I2M-1-012）