目的 觀察六味能消膠囊聯(lián)合非諾貝特和辛伐他汀治療混合性高脂血癥的臨床療效。方法 選取2015年7月—2016年6月在澄邁縣人民醫(yī)院就診的混合性高脂血癥患者106例，隨機(jī)分為對(duì)照組和治療組，每組各53例。對(duì)照組口服非諾貝特膠囊，200 mg/次，1次/d；同時(shí)晚睡前口服辛伐他汀片，20 mg/次，1次/d。治療組在對(duì)照組的基礎(chǔ)上口服六味能消膠囊，1粒/次，3次/d。兩組均連續(xù)治療8周。比較兩組治療前后臨床療效和血脂水平。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為79.24%、90.57%，兩組總有效率比較差異有統(tǒng)計(jì)學(xué)意義（P < 0.05）。治療后，兩組患者三酰甘油（TG）、總膽固醇（TC）和低密度脂蛋白膽固醇（LDL-C）水平顯著下降，高密度脂蛋白膽固醇（HDL-C）水平明顯升高，同組治療前后差異具有統(tǒng)計(jì)學(xué)意義（P < 0.05）；且治療組上述血脂指標(biāo)水平改善優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P < 0.05）。結(jié)論 六味能消膠囊聯(lián)合非諾貝特和辛伐他汀治療混合性高脂血癥臨床療效確切，可顯著降低血脂水平，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To observe the clinical effect of Liuwei Nengxiao Capsules combined with fenofibrate and simvastatin in treatment of mixed hyperlipidemia. Methods Patients (106 cases) with mixed hyperlipidemia in Chengmai County People's Hospital from July 2015 to June 2016 were randomly divided into control and treatment groups, and each group had 53 cases. Patients in the control group were po administered with Fenofibrate Capsules, 200 mg/time, once daily. And they were also po administered with Simvastatin Tablets before going to bed, 20 mg/time, once daily. Patients in the treatment group were po administered with Liuwei Nengxiao Capsules on the basis of the control group, 1 grain/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy and blood lipid levels in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 79.24% and 90.57% respectively, and there was difference between two groups (P < 0.05). After treatment, the TG, CHO, and LDL-C levels in two groups were significantly decreased, but the HDL-C level was significantly increased, and the difference was statistically significant in the same group (P < 0.05). And these blood lipid levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Liuwei Nengxiao Capsules combined with fenofibrate and simvastatin has an obvious clinical curative effect in treatment of mixed hyperlipidemia, can significantly decrease blood lipid levels, which has a certain clinical application value.