目的 探討鼻淵通竅顆粒聯(lián)合莫西沙星治療急性鼻竇炎的臨床療效。方法 選取2015年10月—2016年10月在南方醫(yī)科大學(xué)南方醫(yī)院接收治療的急性鼻竇炎患者150例，隨機(jī)分為對照組（75例）和治療組（75例）。對照組患者口服鹽酸莫西沙星片，1片/次，1次/d。治療組在對照組的基礎(chǔ)上口服鼻淵通竅顆粒，1袋/次，3次/d。兩組患者均治療14 d。比較兩組患者臨床療效、臨床癥狀評分和血清炎性因子水平。結(jié)果 治療后，對照組和治療組的總有效率分別為81.33%、96.00%，兩組總有效率比較差異有統(tǒng)計(jì)學(xué)意義（P < 0.05）。治療后，兩組患者鼻塞、鼻涕和頭痛評分均較治療前明顯降低，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P < 0.05）；且治療組比對照組降低更顯著，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P < 0.05）。與治療前相比，治療后兩組患者血清超敏C反應(yīng)蛋白（hs-CRP）、白細(xì)胞介素-6（IL-6）和腫瘤壞死因子-α（TNF-α）水平明顯降低，而IL-10水平明顯升高，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P < 0.05）；且治療組上述血清炎性因子水平改善更明顯，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P < 0.05）。結(jié)論 鼻淵通竅顆粒聯(lián)合莫西沙星治療急性鼻竇炎的臨床效果顯著，可明顯改善患者臨床癥狀和降低血清炎性因子，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To evaluate the clinical efficacy of Biyuan Tongqiao Granules combined with moxifloxacin in treatment of acute sinusitis. Methods Patients (150 cases) with acute sinusitis in Nanfang Hospital of Southern Medical University from October 2015 to October 2016 were randomly divided into control (75 cases) and treatment (75 cases) groups. Patients in the control group were po administered with Moxifloxacin Hydrochloride Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Biyuan Tongqiao Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy, clinical symptom scores, and serum inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.33% and 96.00% respectively, and there was difference between two groups (P < 0.05). After treatment, the nasal congestion, runny nose, and headache scores in two groups significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And these clinical symptom scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Compared with those before treatment, the hs-CRP, IL-6, and TNF-α levels in two groups significantly decreased, but the IL-10 level significantly increased, and the difference was statistically significant in the same group (P < 0.05). And these serum inflammatory factors levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Biyuan Tongqiao Granules combined with moxifloxacin has significant clinical effect in treatment of acute sinusitis, can significantly improve the clinical symptoms and reduce the serum inflammatory factors, which has a certain clinical application value.