目的 探討鹽酸米諾環(huán)素軟膏聯(lián)合碘甘油治療牙周炎的臨床療效。方法 選取2014年2月—2015年9月深圳市鹽田區(qū)人民醫(yī)院收治的90例牙周炎患者107顆患牙作為研究對象，根據(jù)序列號法分為對照組（45例，55顆）和治療組（45例，52顆）。對照組在患牙牙周袋內(nèi)注入碘甘油，用藥1 h內(nèi)禁飲食或漱口，1次/周。治療組在對照組基礎(chǔ)上在患牙牙周袋內(nèi)注入鹽酸米諾環(huán)素軟膏，用藥1 h內(nèi)禁飲食或漱口，1次/周。兩組患者均治療4周。觀察兩組的臨床療效，比較兩組的炎癥指標(biāo)和牙周指標(biāo)情況。結(jié)果 治療后，對照組和治療組的總有效率分別為78.18%、96.15%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P < 0.05）。治療后，兩組高敏C反應(yīng)蛋白（hs-CRP）、腫瘤壞死因子α（TNF-α）、彈性蛋白酶（EA）和前列腺素E₂（PGE₂）水平均顯著下降，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P < 0.05）；且治療組這些觀察指標(biāo)的下降程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P < 0.05）。治療后，兩組牙齦出血指數(shù)（GI）、牙齒松動度（MD）、牙周袋深度（PD）、牙周附著水平（AL）、牙槽骨吸收（ABL）均顯著下降，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P < 0.05）；且治療組這些觀察指標(biāo)的下降程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P < 0.05）。結(jié)論 鹽酸米諾環(huán)素軟膏聯(lián)合碘甘油治療牙周炎具有較好的臨床療效，能降低炎癥反應(yīng)，改善牙周狀況，促進(jìn)牙周組織恢復(fù)，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of minocycline combined with Iodine Glycerol in treatment of periodontitis. Methods Patients (90 cases and 107 teeth) with periodontitis in Shenzhen Yantian District People's Hospital from February 2014 to September 2015 were divided into the control group (45 cases, 55 teeth) and treatment group (45 cases, 52 teeth) according to serial number method. Patients in the control group were injection administered with iodine glycerol in the periodontal bag, no diet or mouthwash within 1 h, once weekly. Patients in the treatment group were injection administered with Minocycline Hydrochloride Ointment in the periodontal bag on the basis of the control group, no diet or mouthwash within 1 h, once weekly. Patients in two groups were treated for four weeks. After treatment, the clinical efficacies were evaluated, and inflammation indexes and periodontal indexes were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 78.18% and 96.15%, respectively, and there was difference between two groups (P < 0.05). After treatment, the levels of hs-CRP, TNF-α, EA and PGE₂ levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, GI, MD, PD, AL and ABL in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Minocycline Hydrochloride Ointment combined with iodine glycerol has clinical curative effect in treatment of periodontitis, can decrease inflammatory response, improve periodontal status, and promote periodontal tissue recovery, which has a certain clinical application value.