目的 探討金水寶膠囊聯(lián)合還原型谷胱甘肽治療急性腎損傷的臨床療效。方法 選取2013年10月—2016年10月在重慶市開州區(qū)人民醫(yī)院住院治療的急性腎損傷患者78例，隨機(jī)分為對(duì)照組和治療組，每組各39例。對(duì)照組靜脈滴注注射用還原型谷胱甘肽，1.2 g溶解在100 mL生理鹽水中，1次/d。治療組在對(duì)照組治療基礎(chǔ)上口服金水寶膠囊，4粒/次，3次/d。兩組均連續(xù)治療1個(gè)月。觀察兩組的臨床療效，比較兩組少尿期和多尿期持續(xù)時(shí)間及血肌酐（Scr）恢復(fù)正常的時(shí)間。比較治療前、治療3、7、14、30 d兩組Scr、內(nèi)生肌酐清除率、尿滲透壓、尿β₂-微球蛋白的變化情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為76.92%、92.31%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P < 0.05）。治療組的少尿期、多尿期的持續(xù)天數(shù)以及血肌酐恢復(fù)正常時(shí)間均顯著短于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P < 0.05）。治療后，兩組Scr、尿β₂-微球蛋白從治療第3天起顯著降低，內(nèi)生肌酐清除率、尿滲透壓從治療3 d開始顯著升高，同組治療前后差異有統(tǒng)計(jì)學(xué)意義（P < 0.05）；治療組在治療7、14、30天Scr低于對(duì)照組，內(nèi)生肌酐清除率高于對(duì)照組；治療組在治療3、7、14、30天尿滲透壓高于對(duì)照組，尿β2-微球蛋白低于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P < 0.05）。結(jié)論 金水寶膠囊聯(lián)合還原型谷胱甘肽治療急性腎損傷具有較好的臨床療效，可降低多尿期、少尿期及血肌酐恢復(fù)正常的時(shí)間，改善患者腎功能，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the effect of Jinshuibao Capsules combined with reduced glutathione in treatment of acute kidney injury. Methods Patients (78 cases) with acute kidney injury in Kaizhou District People's Hospital in Chongqing from October 2013 to October 2016 were randomly divided into control and treatment groups, and each group had 39 cases. Patients in the control group were iv administered with Reduced Glutathione Sodium for injection, 1.2 g added into normal saline 100 mL, once daily. The patients in the treatment group were po administered with Jinshuibao Capsules, 4 grains/time, three times daily. The patients in two groups were treated for 1 month. After treatment, the efficacy was evaluated, and the low urinary time, multiple urine time and Scr recovery time in two groups were compared. The changes of Scr, endogenous creatinine clearance, urine osmotic pressure and urine β₂ microglobulin before treatment and the treatment of 3, 7, 14, and 30 d in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 76.92% and 92.31%, respectively, and there were differences between two groups (P < 0.05). The low urinary time, multiple urine time and Scr recovery time in treatment group were shorter than those in the control group, with significant difference between two groups (P < 0.05). After treatment, Scr and urine β₂ microglobulin in two groups significantly reduced since the third day of treatment, endogenous while endogenous creatinine clearance and urine osmotic pressure significantly increased since the third day of treatment, and the difference was statistically significant in the same group (P < 0.05). The level of Scr in the treatment group was lower than that in the control group on the treatment of 7, 14, and 30 d, and endogenous creatinine clearance rate was higher than that of the control group; Urine osmotic pressure was higher than that of the control group on the treatment for 3, 7, 14, and 30 d, β₂ microglobulin was lower than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Jinshuibao Capsules combined with reduced glutathione has clinical curative effect in treatment of acute kidney injury, and can decrease low urinary time, multiple urine time and Scr recovery time, and improve the kidney function, which has a certain clinical application value.