目的 探討定坤丹聯(lián)合來曲唑治療不孕癥的臨床療效。方法 選取2013年3月—2015年3月在南陽市臥龍區(qū)第一人民醫(yī)院接受診治的不孕癥患者76例，隨機(jī)分為對(duì)照組和治療組，每組各38例。對(duì)照組患者于月經(jīng)結(jié)束后3 d開始口服來曲唑片，1片/次，2次/d。治療組在對(duì)照組的基礎(chǔ)上口服定坤丹，1丸/次，2次/d。兩組患者均連續(xù)服用至下次月經(jīng)前2周，連續(xù)服用4個(gè)月。評(píng)價(jià)兩組患者妊娠率，同時(shí)比較兩組治療前后子宮內(nèi)膜厚度、成熟卵泡數(shù)、性激素水平和生活質(zhì)量評(píng)分變化。結(jié)果 治療后對(duì)照組的妊娠率為60.53%，顯著低于治療組的81.58%，兩組妊娠率比較差異有統(tǒng)計(jì)學(xué)意義（P < 0.05）。治療后，兩組患者子宮內(nèi)膜厚度、成熟卵泡數(shù)均高于治療前（P < 0.05）；且與對(duì)照組相比，治療組患者升高的更顯著（P < 0.05）。治療后，兩組患者血清促黃體生成素（LH）顯著升高，卵泡生成激素（FSH）和催乳素（PRL）水平顯著降低，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P < 0.05）；且治療組患者這些性激素水平改善優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P < 0.05）。治療后，兩組各項(xiàng)生活質(zhì)量評(píng)分顯著升高P < 0.05）；且治療組患者這些生活質(zhì)量評(píng)分均高于對(duì)照組，（P < 0.05）。結(jié)論 定坤丹聯(lián)合來曲唑治療不孕癥效果顯著，可明顯改善機(jī)體性激素水平，提高患者生活質(zhì)量，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical efficacy of Dingkundan combined with letrozole in treatment of infertility. Methods Patients (76 cases) with infertility in Wolong District First People's Hospital of Nanyang from March 2013 to March 2015 were randomly divided into control and treatment groups, and each group had 63 cases. Patients in the control group were po administered with Letrozole Tablets 3 d after menstruation, 1 tablet/time, twice daily. Patients in the treatment group were po administered with Dingkundan on the basis of the control group, 1 pill/time, twice daily. Patients in two groups were treated for two weeks before the next menstrual period, and continually treated for four months. After treatment, the pregnancy rate was evaluated, and the endometrial thickness, the number of mature follicles, sex hormone levels, and quality of life scores in two groups were compared. Results After treatment, the pregnancy rate in the control group was 60.53%, which was significantly lower than 81.58% in the treatment group, with significant difference between two groups (P < 0.05). After treatment, the endometrial thickness and the number of mature follicles in two groups significantly increased (P < 0.05). And compared with the control group, the two indexes in the treatment group were significantly higher than those in the control group (P < 0.05). After treatment, the serum LH in two groups significantly increased, but the FSH and PRL significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And these sex hormone levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the life quality scores in two groups significantly increased (P < 0.05). And the life quality scores in the treatment group were significantly higher than those in the control group (P < 0.05).Conclusion Dingkundan combined with letrozole has significant effect in treatment of infertility, can significantly improve the sexual hormone level and the life quality, which has a certain clinical application value.