目的 探討羚羊角膠囊聯(lián)合丙戊酸鈉治療外傷后癲癇的臨床療效。方法 選取2015年2月—2016年10月在天津醫(yī)科大學(xué)總醫(yī)院濱海醫(yī)院進(jìn)行治療的外傷后癲癇患者78例，隨機(jī)分成對(duì)照組（39例）和治療組（39例）。對(duì)照組口服丙戊酸鈉片，15～20 mg/（kg·d），3次/d。治療組在對(duì)照組基礎(chǔ)上口服羚羊角膠囊，0.6 g/次，1次/d。兩組經(jīng)過(guò)4個(gè)月治療后進(jìn)行效果評(píng)價(jià)。評(píng)價(jià)治療后兩組患者臨床療效，同時(shí)比較治療前后兩組血清學(xué)指標(biāo)、睡眠質(zhì)量改善情況和癲癇發(fā)作頻率。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為79.49%和94.87%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P< 0.05）。治療后，兩組患者血清白細(xì)胞介素-6（IL-6）、神經(jīng)元特異性烯醇化酶（NSE）、腦源性神經(jīng)營(yíng)養(yǎng)因子（BDNF）和S100β水平均顯著降低（P< 0.05）；且治療組血清IL-6、NSE、BDNF和S100β水平明顯好于對(duì)照組（P< 0.05）。治療后，兩組患者AIS評(píng)分、ESS評(píng)分和PSQI評(píng)分均明顯下降（P< 0.05）；且治療組AIS評(píng)分、ESS評(píng)分和PSQI評(píng)分明顯低于對(duì)照組（P< 0.05）。治療后，兩組癲癇發(fā)作頻率均比治療前明顯降低（P< 0.05）；且治療組患者癲癇發(fā)作頻率明顯低于對(duì)照組（P< 0.05）。結(jié)論 羚羊角膠囊聯(lián)合丙戊酸鈉片治療外傷后癲癇效果明確，可有效改善患者臨床癥狀及促進(jìn)神經(jīng)功能恢復(fù)，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Lingyangjiao Capsules combined with sodium valproate in treatment of post-traumatic epilepsy. Methods Patients (78 cases) with post-traumatic epilepsy in Coastal Hospital of General Hospital of Tianjin Medical University from February 2015 to October 2016 were randomly divided into control (39 cases) and treatment (39 cases) groups. Patients in the control group were po administered with Sodium Valproate Tablets, 15-20 mg/(kg·d), three times daily. Patients in the treatment group were po administered with Lingyangjiao Capsules on the basis of the control group, 0.6 g/time, once daily. Patients in two groups were treated for 4 months. After treatment, clinical efficacy was evaluated, and the seizure frequency, serological indexes and sleep quality in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 79.49% and 94.87%, respectively, and there were differences between two groups (P < 0.05). After treatment, the IL-6, NSE, BDNF and S100β levels in two groups were significantly decreased (P < 0.05). And the serological indexes in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the AIS, ESS and PSQI scores in two groups were significantly decreased (P < 0.05). And these scores in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the seizure frequencies in two groups were significantly decreased (P < 0.05). And the seizure frequency in the treatment group was significantly lower than that in the control group (P < 0.05). Conclusion Lingyangjiao Capsules combined with sodium valproate has clear curative effect in treatment of post-traumatic epilepsy, and can effectively improve the clinical symptoms and promote the recovery of neurological function, which is worthy of clinical application.