乳腺癌已成為危及女性生命健康最常見(jiàn)的惡性腫瘤之一，若能實(shí)現(xiàn)對(duì)其進(jìn)行早期診斷并積極干預(yù)，會(huì)極大提高患者的生存率。近幾十年來(lái)，核素功能成像特別是PET成像顯著提高了對(duì)乳腺癌各種生物學(xué)過(guò)程的認(rèn)識(shí)能力，為從分子及細(xì)胞水平準(zhǔn)確地診斷乳腺癌提供了可能。目前已有多種乳腺癌PET分子探針被開(kāi)發(fā)，對(duì)代謝類(lèi)、細(xì)胞增殖類(lèi)、雌激素α受體類(lèi)、雌激素β受體類(lèi)、孕激素受體類(lèi)、表皮生長(zhǎng)因子類(lèi)、胃泌素釋放肽類(lèi)、乏氧類(lèi)、氨基轉(zhuǎn)運(yùn)類(lèi)PET分子探針的研究進(jìn)展進(jìn)行綜述。

Breast cancer has become a sever disease that threats to women's health. Early diagnosis and positive intervention of breast cancer will greatly increase the survival rate of patients. In recent decades, radionuclide functional imaging, especially PET imaging, has significantly improved the understanding of various biological processes in breast cancer, and has made the accurate diagnosis of breast cancer at the molecular and cellular levels possible. Research advances ofn PET molecular probes of metabolic, cell proliferation, estrogen receptor α, estrogen receptor β, progesterone receptor, epidermal growth factor, gastrin-releasing peptide receptor, hypoxia, amino transport are reviewed in this paper.

湖北省教育廳科學(xué)研究計(jì)劃指導(dǎo)性項(xiàng)目（B2017578）