目的 探討益腦寧片聯(lián)合阿托伐他汀鈣治療腦動(dòng)脈硬化癥的臨床療效。方法 選取南開(kāi)大學(xué)附屬醫(yī)院于2015年8月-2016年8月收治的腦動(dòng)脈硬化癥患者131例，隨機(jī)分成對(duì)照組（65例）和治療組（66例）。對(duì)照組患者口服阿托伐他汀鈣片，10 mg/次，1次/d；治療組在對(duì)照組的基礎(chǔ)上口服益腦寧片，4片/次，3次/d。所有患者均經(jīng)過(guò)8周治療。評(píng)價(jià)兩組患者臨床療效，同時(shí)比較治療前后兩組患者血液流變學(xué)、疾病相關(guān)指標(biāo)和不良反應(yīng)情況。結(jié)果 對(duì)照組和治療組總有效率分別為81.54%、96.97%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者大腦中動(dòng)脈血流速度顯著升高，頸動(dòng)脈內(nèi)膜中膜厚度、斑塊面積和血管搏動(dòng)指數(shù)均顯著降低，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組患者上述疾病相關(guān)指標(biāo)改善情況均要明顯優(yōu)于對(duì)照組患者（P<0.05）。治療后，兩組患者的血漿黏度、紅細(xì)胞壓積以及紅細(xì)胞聚集指數(shù)均有所降低（P<0.05）；且治療組患者血液流變學(xué)指標(biāo)降低得更為明顯（P<0.05）。治療期間，對(duì)照組不良反應(yīng)發(fā)生率為18.46%，明顯高于治療組的6.06%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 益腦寧片聯(lián)合阿托伐他汀鈣治療腦動(dòng)脈硬化癥療效顯著，可明顯改善疾病相關(guān)指標(biāo)，安全性高，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the clinical efficacy of Yinaoning Tablets combined with atorvastatin calcium in treatment of cerebral arteriosclerosis. Methods Patients (131 cases) with cerebral arteriosclerosis in Affiliated Hospital of Nankai University from August 2015 to August 2016 were randomly divided into control (65 cases) and treatment (66 cases) groups. Patients in the control group were po administered with Atorvastatin Calcium Tablets, 10 mg/time, once daily. Patients in the treatment group were po administered with Yinaoning Tablets on the basis of the control group, 4 tablets/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the blood rheology, other disease indexes, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 81.54% and 96.97%, respectively, and there were differences between two groups (P<0.05). After treatment, the blood flow velocity of middle cerebral artery in two groups was significantly increased, but carotid intima media thickness, plaque area, and vascular pulsatility index were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And these indexes in the treatment group were significantly better than those in the control group (P<0.05). After treatment, plasma viscosity, hematocrit, and red cell assembling indexes in two groups were significantly decreased (P<0.05). And the improvement of the hemorheological indexes in the treatment group were more obvious than those in the control group (P<0.05). During the treatment, the incidence of adverse reactions in the control group was 18.46%, which was significantly higher than 6.06% in the treatment group, with significant difference between two groups (P<0.05). Conclusion Yinaoning Tablets combined with atorvastatin calcium has significant effect in treatment of cerebral arteriosclerosis, can significantly improve disease-related indexes, which has a certain clinical application value.