目的 觀察感咳雙清膠囊聯(lián)合沙丁胺醇治療小兒毛細氣管炎的臨床療效。方法 收集2011年3月-2015年3月在棗莊市婦幼保健院就診的毛細支氣管炎患兒109例，隨機分為對照組（54例）和治療組（55例）。對照組患兒霧化吸入硫酸沙丁胺醇吸入氣霧劑，0.01~0.03 mg/kg加入生理鹽水2 mL。治療組患兒在對照組的基礎(chǔ)上口服感咳雙清膠囊，2粒/次，3次/d。兩組患兒均連續(xù)治療7 d。評價兩組患者臨床療效，同時比較治療前后兩組患兒臨床癥狀消失時間、咳嗽積分和肺功能指標情況。結(jié)果 治療后，對照組的臨床總有效率為81.48%，顯著低于治療組的94.55%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患兒日間和夜間咳嗽評分均明顯降低，同組比較差異具有統(tǒng)計學(xué)意義（P<0.05）；且治療后治療組喘憋、咳嗽、哮鳴音和濕啰音消失時間及咳嗽積分均明顯好于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，治療組患兒呼吸頻率（RR）、潮氣量（VT）、功能殘氣量（FRC）、達峰容積比（VPEF/VE）和達峰時間比（tPTEF/tE）均高于對照組患兒，F(xiàn)RC低于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 感咳雙清膠囊聯(lián)合沙丁胺醇治療兒童毛細支氣管炎能縮短癥狀消失時間，改善呼吸功能，具有一定的臨床推廣應(yīng)用價值。

Objective To observe the clinical effect of Ganke Shuangqing Capsules combined with salbutamol in treatment of children with bronchiolitis. Methods Children (109 cases) with bronchiolitis in Maternity and Child Health Care of Zaozhuang from March 2011 to March 2015 were randomly divided into control (54 cases) and treatment (55 cases) groups. Children in the control group were aerosol inhalation administered with Salbutamol Sulphate Inhalation Aerosol, 0.01-0.03 mg/kg added into normal saline 2 mL. Children in the treatment group were po administered with Ganke Shuangqing Capsules on the basis of the control group, 2 grains/time, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the disappearance time of clinical symptoms, cough scores, and lung function indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 81.48%, which was significantly lower than 94.55% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the daytime and nighttime cough scores in two groups were significantly decreased, and there were differences in the same group (P<0.05). And the disappearance time of shortness of breath, coughing, wheezing and wet rales, and cough scores in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the RR, VT, FRC, VPEF/VE, and tPTEF/tE levels in the treatment group were obviously higher than those in the control group, and FRC level was obviously lower than that in the control group, with significant difference between two groups (P<0.05). Conclusion Ganke Shuangqing Capsules combined with salbutamol can shorten the symptoms disappearance time and improve respiratory function in treatment of children with bronchiolitis, which has a certain clinical application value.