目的 探討甘草甜素片聯(lián)合注射用丁二磺酸腺苷蛋氨酸治療肝內(nèi)膽汁淤積性肝炎的臨床療效。方法 選取2015年1月-2017年1月陜西省人民醫(yī)院收治的肝內(nèi)膽汁淤積性肝炎患者64例作為研究對(duì)象，所有患者隨機(jī)分為對(duì)照組和治療組，每組各32例。對(duì)照組靜脈滴注注射用丁二磺酸腺苷蛋氨酸，1.0 g加入到15%葡萄糖溶液250 mL中，1次/d。治療組在對(duì)照組基礎(chǔ)上口服甘草甜素片，150 mg/次，2次/d。兩組患者均連續(xù)治療4周。觀察兩組的臨床療效，比較兩組的癥狀改善和肝功能情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為78.1%、96.9%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組乏力、惡心嘔吐、腹脹、灰白便、皮膚瘙癢的比例均明顯下降，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)明顯低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組丙氨酸氨基轉(zhuǎn)移酶（ALT）、血清總膽紅素（TBIL）、γ-谷氨酰轉(zhuǎn)移酶（γ-GT）、堿性磷酸酶（ALP）、總膽汁酸（TBA）水平均明顯降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)明顯低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 甘草甜素片聯(lián)合注射用丁二磺酸腺苷蛋氨酸治療肝內(nèi)膽汁淤積性肝炎具有較好的臨床療效，可改善臨床癥狀和肝功能指標(biāo)，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the efficacy of Glycyrrhizin Tablets combined with Ademetionine 1,4-Butanedisulfonate for injection in treatment of intrahepatic cholestasis hepatitis. Methods Patients (64 cases) with intrahepatic cholestasis hepatitis in Shaanxi Provincial People's Hospital from January 2015 to January 2017 were randomly divided into control and treatment groups, and each group had 32 cases. Patients in the control group were iv administered with Ademetionine 1,4-Butanedisulfonate for injection, 1.0 g added into 15% glucose solution 250 mL, once daily. Patients in the treatment group were po administered with Glycyrrhizin Tablets on the basis of the control group, 150 mg/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and symptom improvement and liver function in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 78.1% and 96.9%, respectively, and there was difference between two groups (P<0.05). After treatment, the proportion of fatigue, nausea, vomiting, abdominal distension, gray stools, and skin itch in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of ALT, TBIL, γ-GT, ALP, and TBA in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Glycyrrhizin Tablets combined with Ademetionine 1,4-Butanedisulfonate for injection has clinical curative effect in treatment of intrahepatic cholestasis hepatitis, can improve clinical symptom and liver function, which has a certain clinical application value.