目的 探討卡前列素氨丁三醇注射液聯(lián)合縮宮素注射液治療子宮收縮乏力性出血的臨床療效。方法 選取2015年1月-2017年5月西安市中心醫(yī)院收治的子宮收縮乏力性出血產(chǎn)婦130例進(jìn)行研究，所有產(chǎn)婦按隨機(jī)數(shù)字表法分為對(duì)照組和治療組，每組各65例。對(duì)照組在實(shí)施麻醉誘導(dǎo)前子宮肌壁注射縮宮素注射液10 U，然后改為靜脈滴注，10 U加入到5%葡萄糖溶液500 mL中。治療組在對(duì)照組基礎(chǔ)上臀部肌內(nèi)注射卡前列素氨丁三醇注射液，250 U/次，1.5~2 h重復(fù)注射1次，總注射劑量<2 000 U。觀察兩組的臨床療效，比較兩組的臨床指標(biāo)、凝血指標(biāo)和卵巢功能。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為80.00%、93.84%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組出血量、輸血量均低于對(duì)照組，宮縮持續(xù)時(shí)間、住院時(shí)間、止血起效時(shí)間均短于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療3 d后，兩組分泌凝血活酶時(shí)間（APTT）、凝血酶原時(shí)間（PT）、纖維蛋白原（FIB）水平均顯著升高，D-二聚體（D-D）水平均顯著下降，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后3個(gè)月，兩組卵泡生成激素（FSH）、黃體生成激素（LH）水平均顯著降低，雌二醇（E₂）水平顯著升高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 卡前列素氨丁三醇注射液聯(lián)合縮宮素注射液治療子宮收縮乏力性出血具有較好的臨床療效，可顯著改善產(chǎn)婦的凝血功能，減少出血，調(diào)節(jié)激素水平，安全性良好，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Carboprost Tromethamine Injection combined with Oxytocin Injection in treatment of uterine atony hemorrhage. Methods Puerpera (130 cases) with uterine atony hemorrhage in Xi'an Central Hospital from February 2015 to May 2017were randomly divided into control and treatment groups, and each group had 65 cases. Puerpera in the control group were injection administered with Oxytocin Injection 10 U into the uterine wall before the induction of anesthesia, then instead of intravenous drip, 10 U added into 5% glucose solution 500 mL. Puerpera in the treatment group were intramuscular injection administered with Carboprost Tromethamine Injection ati the hips on the basis of the control group, 250 U/time, after 1.5 to 2 h, repeated injections 1 time. Total injection dose is less than 2 000 U. After treatment, the clinical efficacies were evaluated, and clinical indicators, blood coagulation indexes, and ovarian function in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 93.84%, respectively, and there was difference between two groups (P<0.05). After treatment for 3 d, the amounts of bleeding and blood transfusion in the treatment group were lower than those in the control group, but contraction duration, hospitalization time, and onset time of hemostasis in the treatment group were shorter than those in the control group, and there was difference between two groups (P<0.05). Three months after treatment, the levels of APTT, PT, and FIB in two groups were significantly increased, but the levels of D-D in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of FSH and LH in two groups were significantly decreased, but the level of E₂ in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Carboprost tromethamine combined with oxytocin has clinical curative effect in treatment of uterine atony hemorrhage, can significantly improve the coagulation function, decrease the amount of bleeding, and regulate hormone level, with good safety, which has a certain clinical application value.