目的 探討陰道內(nèi)置與舌下含化米索前列醇在門診無痛人流中的應用療效。方法 選取2015年11月-2016年11月深圳市龍華新區(qū)中心醫(yī)院婦科門診行無痛人流手術的孕早期婦女170例為研究對象，隨機分為陰道內(nèi)置組和舌下含化組，每組各85例。分別于術前3 h陰道內(nèi)置與舌下含化米索前列醇片400 μg，再實施常規(guī)的無痛人工流產(chǎn)操作。觀察兩組的臨床療效，比較兩組的手術時間、術中出血量及不良反應發(fā)生情況。結果 陰道內(nèi)置組和舌下含化組的總有效率分別為96.47%、97.64%，兩組總有效率比較差異無統(tǒng)計學意義；陰道內(nèi)置組的手術時間短于舌下含化組，而陰道內(nèi)置組的術中出血量多于舌下含化組，兩組比較差異均無統(tǒng)計學意義。舌下含化組患者的術前陰道出血和下腹痛的發(fā)生率明顯低于陰道內(nèi)置組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。結論 米索前列醇通過陰道內(nèi)置與舌下含化這兩種給藥途徑均可以有效的擴張宮頸，特別是，舌下含化給藥方式，用藥方便、吸收效果好，避免了陰道內(nèi)置給藥的不便和相關不良反應，一般情況下可首選，而對于妊娠反應重或不適合舌下含化的患者，更適宜選擇陰道內(nèi)置給藥方式，故醫(yī)師在臨床用藥時可根據(jù)患者的實際情況選擇合適的給藥途徑。

Objective To explore the curative effect of vaginal implantation and sublingual misoprostol in outpatient painless flow. Methods Early pregnancy women (170 cases) with painless flow in Department of Gynecology in Shenzhen Longhua New District Central Hospital from November 2015 to November 2016 were randomly divided into vaginal implantation and sublingual groups, and each group had 85 cases. Patients were vaginal implantation and sublingual with Misoprostol Tablets, 400 μg, respectively. Then they were given the implementation of conventional painless abortion. The clinical efficacies were evaluated, and operation time, peroperative bleeding volum, and adverse reaction in two groups were compared. Results The clinical efficacies in the control and treatment groups were 96.47% and 97.64%, respectively, and there was no difference between two groups. Operation time in vaginal implantation group was lower than that in the treatment group, while peroperative bleeding volum in vaginal implantation group was more than that in the treatment group, but there was no significant difference between two groups. The occurrence rate of preoperative vaginal bleeding in vaginal implantation groups and lower abdominal pain were lower than those in sublingual group, and there was difference between two groups (P<0.05). Conclusion Misoprostol can effectively expand the cervix through vaginal implantation and sublingual administration. In particular, the sublingual administration is convenient with good absorption, and it can avoid the inconvenience of vaginal implantation and related adverse reactions, which can be preferred. For patients with serious pregnancy reaction or those unsuitable for sublingual, it is more appropriate to choose vaginal implantation. Therefore, physician choose appropriate route of administration according to the actual situation of patients in the clinical medication.