目的 探討參麥注射液致藥品不良反應(yīng)的特點(diǎn)及相關(guān)因素，為臨床合理用藥提供參考。方法 檢索2007年1月-2017年6月中國(guó)學(xué)術(shù)期刊（網(wǎng)絡(luò)版）、萬(wàn)方數(shù)字化期刊全文庫(kù)、中文科技期刊全文數(shù)據(jù)庫(kù)（維普）及PubMed數(shù)據(jù)庫(kù)收錄的全部中醫(yī)藥期刊，收集報(bào)道參麥注射液致不良反應(yīng)的文獻(xiàn)進(jìn)行統(tǒng)計(jì)和分析。結(jié)果 參麥注射液引發(fā)的不良反應(yīng)女性明顯多于男性，年齡多集中在41~60歲，在用藥10 min以內(nèi)出現(xiàn)不良反應(yīng)的例數(shù)最多，占45.76%，以心血管和皮膚及附件損害較為多見(jiàn)，所占構(gòu)成比分別為30.69%、15.93%。結(jié)論 臨床應(yīng)加強(qiáng)參麥注射液的合理使用，盡量避免或減少其所致不良反應(yīng)的發(fā)生。

Objective To investigate the characteristics and relative factors of adverse drug reaction (ADR) induced by Shenmai Injection, and to provide references for clinical rational drug use. Methods Chinese Academic Journal (online), Wangfang Database, Chinese Science and Technology Journal Full-text Database (VIP), and PubMed databases were retrieved from January 2007 to June 2017, and the documents of ADR induced by Shenmai Injection were analyzed and discussed. Results Women with ADR induced by Shenmai Injection were more than men, and more were focused on 41-60 years old. The most cases (45.76%) occured within the medication 10 min. Organs/systems involved by ADR mainly were cardiovascular, skin and accessory injury, accounting for 30.69% and 15.93%, respectively. Conclusion More attention should be paid on the rational use of Shenmai Injection to reduce or avoid the occurrence of adverse reactions.

國(guó)家科技支撐計(jì)劃項(xiàng)目（2007BAI47B00）