目的 探討克感利咽顆粒聯(lián)合奧司他韋治療兒童流行性感冒的臨床療效。方法 收集廣州市婦女兒童醫(yī)療中心2015年4月—2017年5月收治的流行性感冒患兒112例，隨機(jī)分為對照組和治療組，每組各56例。對照組患兒口服磷酸奧司他韋膠囊，2 mg/kg，2次/d。治療組在對照組基礎(chǔ)上口服克感利咽顆粒，1袋/次，2次/d。兩組患兒均連續(xù)治療5 d。觀察兩組患者臨床療效，比較治療前后兩組患兒臨床癥候積分和癥狀緩解時(shí)間。結(jié)果 治療后，對照組和治療組臨床總有效率分別為92.86%和100.00%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組發(fā)熱、鼻塞流涕、咳嗽咯痰、頭痛、惡寒和全身乏力積分均較治療前明顯降低，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組各臨床癥狀積分均明顯低于對照組，同時(shí)治療組鼻塞流涕、咳嗽咯痰、惡寒和全身乏力的緩解時(shí)間相比對照組明顯縮短，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 克感利咽顆粒聯(lián)合奧司他韋治療兒童流行性感冒可顯著縮短臨床癥狀緩解時(shí)間，提高臨床治療效果。

objective To study the curative effect of Kegan Liyan Granules combined with oseltamivir in treatment of children with influenza. Methods Children (112 cases) with influenza in Guangzhou Women and Children's Medical Center from April 2015 to May 2017 were randomly divided into control and treatment groups, and each group had 56 cases. Children in the control group were po administered with Oseltamivir Phosphate Capsules, 2 mg/kg, twice daily. Children in the treatment group were po administered with Kegan Liyan Granules on the basis of the control group, 1 bag/time, twice daily. Children in two groups were treated for 5 d. After treatment, the clinical efficacy was evaluated, and the clinical symptoms scores and symptom alleviative time in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 92.86% and 100.0%, respectively, and there were differences between two groups (P < 0.05). After treatment, the fever, stuffy running nose, cough and expectoration, headache, aversion to cold and malaise scores in two groups were significantly decreased, and there were differences in the same group (P < 0.05). And the clinical symptoms scores in the treatment group were significantly lower than those in the control group, and the alleviative time of stuffy running nose, cough and expectoration, aversion to cold and malaise in the treatment group was significantly shorter than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Kegan Liyan Granules combined with oseltamivir in treatment of children with influenza can significantly shorten the time of relief symptom and improve the clinical efficacy.