目的 探討銀杏葉片聯(lián)合鹽酸法舒地爾注射液治療冠心病慢性心力衰竭的臨床療效。方法 選取2016年6月-2017年9月涼山彝族自治州第一人民醫(yī)院收治的冠心病合并慢性心力衰竭患者98例為研究對(duì)象，患者隨機(jī)被分為對(duì)照組和治療組，每組各49例。對(duì)照組靜脈滴注鹽酸法舒地爾注射液，30 mg加入到5%葡萄糖溶液100 mL中，2次/d，10 d為1個(gè)療程，每個(gè)月治療1個(gè)療程。治療組在對(duì)照組基礎(chǔ)上口服銀杏葉片，1片/次，3次/d。兩組患者均連續(xù)治療3個(gè)月。觀察兩組的臨床療效，比較兩組的6 min步行距離、心功能分級(jí)、超聲心動(dòng)圖指標(biāo)、血清生化指標(biāo)。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為77.6%、91.8%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組6 min步行距離均明顯增加，心功能分級(jí)均明顯改善，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組左心室舒張末期內(nèi)徑（LVEDD）、左心室收縮末期內(nèi)徑（LVESD）均顯著降低，左室射血分?jǐn)?shù)（LVEF）、每搏量（SV）均顯著升高，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組血清腦鈉肽（BNP）、白細(xì)胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）水平均顯著降低，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)明顯低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 銀杏葉片聯(lián)合鹽酸法舒地爾注射液治療冠心病慢性心力衰竭具有較好的臨床療效，可改善患者的心功能，降低炎性指標(biāo)，提高運(yùn)動(dòng)能力，安全性較好，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effects of Yinxingye Tablets combined with Fasudil Hydrochloride Injection in treatment of chronic heart failure of coronary heart disease. Methods Patients (92 cases) with chronic heart failure of coronary heart disease in the First People's Hospital of Liangshan Yi Autonomous Prefecture from June 2016 to September 2017 were randomly divided into control and treatment groups, and each group had 49 cases. Patients in the control group were iv administered with Fasudil Hydrochloride Injection, 30 mg added into 5% glucose solution 100 mL, twice daily, 10 d/course, 1 course/month. Patients in the treatment group were po administered with Yinxingye Tablets on the basis of the control group, 1 tablet/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and 6 min walking distance, cardiac function classification, echocardiographic indexes, and serum biochemical indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 77.6% and 91.8%, respectively, and there was difference between two groups (P < 0.05). After treatment, the 6 min walking distance in two groups were significantly increased, and cardiac function classifications in two groups were significantly improved, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, LVEDD and LVESD in two groups were significantly decreased, but LVEF and SV in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of BNP, IL-6, and TNF-α in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Yinxingye Tablets combined with Fasudil Hydrochloride Injection has clinical curative effect in treatment of chronic heart failure of coronary heart disease, can improve the heart function, decrease the inflammatory index, and improve exercise ability, with good safety, which has a certain clinical application value.