目的 探討開喉劍噴霧劑聯(lián)合腫痛安膠囊治療兒童皰疹性口腔炎的臨床效果。方法 選擇北京懷柔醫(yī)院2015年3月—2017年6月就診的兒童皰疹性口腔炎患兒92例為研究對象，隨機(jī)分為對照組和治療組，每組各46例。對照組患者外敷腫痛安膠囊，將1粒腫痛安膠囊中的藥粉以少量香油調(diào)成糊狀，無菌棉簽蘸取敷于創(chuàng)面，同時口服腫痛安膠囊，2粒/次，3次/d。治療組在對照組的基礎(chǔ)上將開喉劍噴霧劑噴于患處，2噴/次，4～5次/d。開喉劍噴霧劑與腫痛安膠囊外敷間隔1 h。兩組均連續(xù)治療1周。治療后，觀察兩組患者的臨床療效，比較兩組癥狀體征緩解時間和外周血白細(xì)胞計數(shù)（WBC）、血清C反應(yīng)蛋白（CRP）水平。結(jié)果 治療后，對照組和治療組的總有效率分別為78.26%、95.65%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，治療組退熱時間、疼痛、流涎消失時間、潰瘍消退時間、進(jìn)食恢復(fù)時間均顯著短于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。兩組外周血WBC和血清CRP水平均較治療前明顯降低，同組治療前后比較差異具有統(tǒng)計學(xué)意義（P<0.05）；且治療后治療組外周血WBC、血清CRP水平均顯著低于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 開喉劍噴霧劑聯(lián)合腫痛安膠囊治療兒童皰疹性口腔炎療效顯著，可迅速緩解患兒疼痛、流涎、潰瘍等癥狀，促進(jìn)炎癥反應(yīng)的緩解，安全性高，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of Kaihoujian Spray combined with Zhongtong'an Capsules in treatment of herpes stomatitis in children. Methods Patients (92 cases) with herpes stomatitis in children in Beijing Huairou Hospital from March 2015 to June 2016 were randomly divided into control and treatment groups, and each group had 46 cases. Patients in the control group were given 1 grain of Zhongtong'an Capsules. The powder was made a paste with a small amount of sesame oil, and was applied to the wound. At the same time, patients in the control group were po administered with Zhongtong'an Capsules, 2 grains/time, three times daily. Patients in the treatment group were given Kaihoujian Spray, 2 sprays/time, 4-5 times/d. The use of Kaihoujian Spray and external application of Zhongtong'an Capsules had an interval of 1 h. Patients in two groups were treated for 1 week. After treatment, the clinical efficacies were evaluated, and response duration of symptoms and signs, WBC, and CRP levels in two groups were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 78.26% and 95.65%, respectively, and there was difference between two groups (P < 0.05). After treatment, fever clearance time, disappearance time of pain, salivation, and ulceration, and feeding recovery time were shorter than those in the control group, and there was difference between two groups (P < 0.05). WBC level in peripheral blood and CRP level in serum in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And WBC and CRP levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Kaihoujian Spray combined with Zhongtong'an Capsules has good effect in treatment of herpes stomatitis in children, can quickly relieve pain, salivation, ulcers and other symptoms, and promote the relief of inflammatory response with high safety, which has a certain clinical application value.