目的 探討紅核婦潔洗液聯(lián)合克霉唑陰道片治療霉菌性陰道炎的臨床療效。方法 選取2015年12月-2016年12月在河南省省立醫(yī)院進行治療的霉菌性陰道炎患者92例，隨機將患者分為對照組（46例）和治療組（46例）。對照組陰道深部放入克霉唑陰道片，1片/d；治療組在對照組基礎(chǔ)上陰道沖洗和外陰擦洗紅核婦潔洗液，與清水按1：10稀釋，2次/d。兩組均經(jīng)過10 d治療。評價兩組患者臨床療效，同時比較治療前后兩組患者臨床癥狀、GQOLI-74量表評分、血清炎癥指標(biāo)和霉菌檢出率。結(jié)果 治療后，對照組臨床有效率為80.43%，顯著低于治療組的95.65%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組臨床癥狀評分顯著降低（P<0.05），GQOLI-74量表評分顯著升高（P<0.05），同時治療組治療后臨床癥狀和GQOLI-74量表評分明顯優(yōu)于對照組（P<0.05）。治療后，兩組血清IL-1β、單核細(xì)胞趨化蛋白-1（MCP-1）、腫瘤壞死因子-α（TNF-α）水平均顯著降低（P<0.05），IL-2、干擾素-γ（IFN-γ）水平均顯著升高（P<0.05），同時治療后治療組上述血清炎癥指標(biāo)明顯優(yōu)于對照組（P<0.05）。治療后，對照組霉菌轉(zhuǎn)陰率為52.17%，明顯低于治療組的86.96%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 紅核婦潔洗液聯(lián)合克霉唑陰道片治療霉菌性陰道炎可有效改善患者臨床癥狀，利于炎癥消退和陰道內(nèi)環(huán)境的改善。

Objective To explore the clinical efficacy of Honghe Fujie Lotion combined with Clotrimazole Vaginal Tablets in treatment of colpitis mycotica. Methods Patients (92 cases) with colpitis mycotica in Henan Province Hospital from December 2015 to December 2016 were randomly divided into control (46 cases) and treatment (46 cases) groups. Patients in the control group were vagina deeply administered with Clotrimazole Vaginal Tablets, 1 tablet/d. Patients in the treatment group were vaginal rinsing and vulvar scrubbing administered with Honghe Fujie Lotion on the basis of the control group, diluted with clear water in proportion of 1:10, twice daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacy was evaluated, and the clinical symptom, GQOLI-74 scale scores, the serum inflammatory markers and mycete detection rate in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 80.43%, which was significantly lower than 95.65% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the clinical symptom scores in two groups were significantly decreased (P<0.05), but the GQOLI-74 scores were significantly increased (P<0.05), and these scores in the treatment group after treatment were significantly better than those in the control group (P<0.05). After treatment, the serum IL-1β, MCP-1 and TNF-α levels in two groups were significantly decreased (P<0.05), but the IL-2 and IFN-γ levels were significantly increased (P<0.05), and the serum inflammatory markers in the treatment group after treatment were significantly better than those in the control group (P<0.05). After treatment, the mycete detection rate in the control group was 52.17%, which was significantly lower than 86.96% in the treatment group, with significant difference between two groups (P<0.05). Conclusion Honghe Fujie Lotion combined with Clotrimazole Vaginal Tablets in treatment of colpitis mycotica can effectively improve the clinical symptoms, and which is conducive to inflammation resolution and improvement of the vagina microecosystem.