目的 探討欖香烯注射液聯(lián)合曲妥珠單抗治療局部晚期乳腺癌的臨床療效。方法 選取2016年2月-2017年5月在海南醫(yī)學院第一附屬醫(yī)院治療的局部晚期乳腺癌患者72例，隨機將患者分為對照組（36例）和治療組（36例）。對照組靜脈滴注注射用曲妥珠單抗，首劑量8 mg/kg加入500 mL生理鹽水，維持劑量6 mg/kg，1次/21 d。治療組在對照組基礎上經(jīng)股動脈穿刺注入欖香烯注射液，100 mL/次，1次/7 d。3周為1個療程，兩組均治療4個療程。評價兩組患者臨床療效，同時比較治療前后兩組患者QLQ-C30評分和血清學指標。結果 治療后，對照組客觀緩解率為33.33%，疾病控制率為63.89%均分別顯著低于治療組的55.56%和83.33%，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組QLQ-C30評分均明顯升高，同組比較差異具有統(tǒng)計學意義（P<0.05）；且治療組QLQ-C30評分顯著高于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組CA125、CA153、腫瘤特異生長因子（TSGF）水平均顯著降低，干擾素-γ（IFN-γ）和IL-2水平顯著升高，同組比較差異具有統(tǒng)計學意義（P<0.05）；且治療組上述血清學指標治療后水平明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。結論 欖香烯注射液聯(lián)合曲妥珠單抗治療局部晚期乳腺癌可有效改善機體細胞因子水平，利于改善患者生活質量，具有一定的臨床推廣應用價值。

Objective To investigate the clinical efficacy of Elemene Injection combined with trastuzumab in treatment of locally advanced breast cancer. Methods Patients (72 cases) with locally advanced breast cancer in the First Affiliated Hospital of Hainan Medical University from February 2016 to May 2017 were randomly divided into control (36 cases) and treatment (36 cases) groups. Patients in the control group were iv administered with Trastuzumab Injection, the first dose was 8 mg/kg, and it was added into normal saline 500 mL, and the maintenance dose was 6 mg/kg, once every 21 d. Patients in the treatment group were puncture injection administered with Elemene Injection via femoral artery on the basis of the control group, 100 mL/time, once every 7 d. 3 weeks as a course of treatment, and patients in two groups were treated for 4 courses of treatment. After treatment, the clinical efficacy was evaluated, and the QLQ-C30 scores and the serological indexes in two groups before and after treatment were compared. Results After treatment, the objective remission rate in the control group was 33.33%, and the disease control rate was 63.89%, which were significantly lower than 55.56% and 83.33% in the treatment group, respectively, and there were differences between two groups (P<0.05). After treatment, the QLQ-C30 scores in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the QLQ-C30 scores in the treatment group after treatment were significantly higher than those in the control group, with significant difference between two groups (P<0.05). After treatment, the CA125, CA153 and TSGF levels in two groups were significantly decreased, but IFN-γ and IL-2 levels were significantly increased, and there were differences in the same group (P<0.05). And the serological indexes in the treatment group after treatment were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Elemene Injection combined with trastuzumab in treatment of locally advanced breast cancer can effectively improve the cytokine level and the quality of life, which has a certain clinical application value.

海南省重點科技計劃項目（ZDYF2016107）