目的 探討舒腦欣滴丸對急性血瘀模型大鼠血小板聚集和血液流變學(xué)指標(biāo)的影響。方法 選取70只Wistar大鼠，隨機(jī)分為對照組，模型組，舒腦欣滴丸13、26、52 mg/kg組，陽性藥腦心通膠囊（15 mg/kg）、阿司匹林腸溶片（15 mg/kg）和藻酸雙脂鈉片（90 mg/kg）組，連續(xù)ig給藥7 d，1次/d，末次給藥后1 h，采用sc 0.1%腎上腺素加在冰水中游泳的方法，制備大鼠急性血瘀模型，觀察舒腦欣滴丸對不同血小板聚集誘導(dǎo)劑二磷酸腺苷（ADP）、花生四烯酸（AA）和膠原（CG）引起的大鼠血小板聚集影響；通過檢測血液流變學(xué)指標(biāo)、凝血功能評價(jià)舒腦欣滴丸對血瘀模型大鼠的作用。結(jié)果 舒腦欣滴丸對3種不同血小板聚集誘導(dǎo)劑引起的血小板聚集均有不同程度的抑制作用，可顯著降低全血黏度，延長血瘀模型大鼠凝血酶原時(shí)間（PT）、活化部分凝血活酶時(shí)間（APTT）。結(jié)論 舒腦欣滴丸13、26、52 mg/kg具有明顯活血化瘀作用，能降低血液黏度，抑制多種誘導(dǎo)劑引起的血小板聚集，具有一定抗凝活性。

Objective To investigate the effect of Shunaoxin Dropping Pills on platelet aggregation and hemorheology in rats with acute blood stasis. Methods Wistar rats (70 cases) were randomly divided into control group, model group, Shunaoxin Dropping Pills (13, 26 and 52 mg/kg) groups, positive drugs Naoxintong Capsules (15 mg/kg), Aspirin Enteric-coated Tablets (15 mg/kg), and Alginic Sodium Diester Tablets (90 mg/kg) groups. Rats were administrated continuously for 7 d, once daily. One hour after the last administration, the rats were injected sc with 0.1% adrenaline and swimming in ice water to prepare acute blood stasis model. The effects of Shunaoxin Dropping Pills on platelet aggregation induced by adenosine diphosphate (ADP), arachidonic acid (AA), and collagen (CG) were observed. The effects of Shunaoxin Dropping Pills on blood stasis model rats were evaluated by detecting hemorheology indexes and coagulation function. Results Shunaoxin Dropping Pills had different inhibitory effects on platelet aggregation induced by three kinds of platelet aggregation inducers. Shunaoxin Dropping Pills could reduce blood viscosity, and prolong prothrombin time (PT) and activated partial thromboplastin time (APTT) of rats with blood stasis. Conclusion Shunaoxin Dropping Pills (13, 26, and 52 mg/kg) can obviously promote blood circulation, remove blood stasis, reduce blood viscosity, and inhibit platelet aggregation caused by various inducers, and have certain anticoagulant activity.

R285.5

天津市第二批特支計(jì)劃青年拔尖人才基金資助項(xiàng)目（TJTZJHQNBJRC-2-7）