目的 探討刺五加腦靈液聯(lián)合扎來普隆片治療失眠癥的臨床療效。方法 選擇2018年2月-2019年2月在成都市第四人民醫(yī)院診治的失眠癥患者86例，根據(jù)用藥的差別分為對照組（43例）和治療組（43例）。對照組睡前口服扎來普隆片，5 mg/次，1次/d；治療組在對照組的基礎(chǔ)上口服刺五加腦靈液，10 mL/次，2次/d。兩組患者均經(jīng)10 d治療。觀察兩組患者臨床療效，同時比較治療前后兩組患者PSQI、AIS、PHQ-9、WEMWBS和QLQ-C30評分，睡眠質(zhì)量以及血清血清5-羥色胺（5-HT）、腦源性神經(jīng)營養(yǎng)因子（BDNF）、白細胞介素-1β（IL-1β）、食欲素A（Orexin-A）、腫瘤壞死因子-α（TNF-α）和IL-2水平。結(jié)果 治療后，對照組臨床有效率為81.40%，顯著低于治療組的97.67%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。經(jīng)治療，兩組患者PSQI評分、AIS評分和PHQ-9評分均顯著降低（P<0.05），但WEMWBS評分和QLQ-C30評分均顯著升高（P<0.05），且治療組這些評分項目改善更明顯（P<0.05）。經(jīng)治療，兩組患者總睡眠時間、REM睡眠時間、睡眠效率均提高（P<0.05），而睡眠潛伏期、覺醒時間均顯著縮短（P<0.05），且以治療組改善最為明顯（P<0.05）。經(jīng)治療，兩組患者血清5-HT、BDNF水平均明顯升高（P<0.05），但IL-1β、Orexin-A、TNF-α、IL-2水平均明顯降低（P<0.05），且以治療組改善最為明顯（P<0.05）。結(jié)論 刺五加腦靈液聯(lián)合扎來普隆片治療失眠癥可顯著改善睡眠情況，提高生活質(zhì)量，有利于焦慮抑郁狀態(tài)和心理健康狀態(tài)改善。

Objective To explore the clinical efficacy of Ciwujia Naoling Solution combined with zaleplon in treatment of insomnia. Methods Patients (86 cases) with insomnia in Chengdu Fourth People's Hospital from February 2018 to February 2019 were divided into control (43 cases) and treatment (43 cases) groups based on different treatments. Patients in the control group were po administered with Zaleplon Tablets, 5 mg/time, once daily. Patients in the treatment group were po administered with Ciwujia Naoling Solution on the basis of the control group, 10 mL/time, twice daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacy was evaluated, and the PSQI, AIS, PHQ-9, WEMWBS and QLQ-C30 scores, sleep quality, and serum levels of 5-HT, BDNF, IL-1β, Orexin-A, TNF-α and IL-2 in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 81.40%, which was significantly lower than 97.67% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the PSQI, AIS, and PHQ-9 scores in two groups were significantly decreased (P < 0.05), but WEMWBS and QLQ-C30 scores were significantly increased (P < 0.05), and these scores in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the total sleep time, sleep time of REM, and sleep efficiency in two groups were significantly increased (P < 0.05), but sleep latency and wake-up time were significantly decreased (P < 0.05), and these indexes in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the serum levels of 5-HT and BDNF in two groups were significantly increased (P < 0.05), but the IL-1β, Orexin-A, TNF-α and IL-2 levels were significantly decreased (P < 0.05), and these serological indexes in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion Ciwujia Naoling Solution combined with zaleplon in treatment of insomnia can significantly improve sleep, improve quality of life, anxiety, depression and mental health.

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