目的 探討小兒清熱片聯(lián)合康復(fù)新液治療兒童口腔潰瘍的臨床效果。方法 選取2016年1月-2019年1月北京兒童醫(yī)院收治的86例口腔潰瘍患兒，隨機(jī)分成對(duì)照組（43例）和治療組（43例）。對(duì)照組餐后含漱康復(fù)新液5 min后吐出，10 mL/次，3次/d。治療組在在對(duì)照組基礎(chǔ)上口服小兒清熱片，2片/次，2次/d。兩組均連續(xù)治療5 d。觀察兩組患兒臨床療效，同時(shí)比較治療前后兩組患兒主要癥狀積分、退熱時(shí)間、食欲改善時(shí)間，外周血白細(xì)胞計(jì)數(shù)（WBC）、中性粒細(xì)胞絕對(duì)值（NEUT#）水平，以及唾液中腫瘤壞死因子-α（TNF-α）、白介素-6（IL-6）、表皮生長(zhǎng)因子（EGF）水平。結(jié)果 治療后，對(duì)照組和治療組臨床有效率分別為86.0%、100.0%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患兒潰瘍面積、充血程度、疼痛積分均顯著低于治療前（P<0.05），且治療組下降更顯著（P<0.05）。治療后，治療組完全退熱時(shí)間、食欲改善時(shí)間較對(duì)照組均顯著縮短（P<0.05）。治療后，兩組患兒外周血WBC、NEUT#水平較治療前均顯著降低（P<0.05），且治療組以上血象指標(biāo)的改善效果比對(duì)照組更顯著（P<0.05）。治療后，兩組患兒唾液中TNF-α、IL-6、EGF水平均顯著下降（P<0.05），且治療組上述唾液指標(biāo)水平均顯著低于對(duì)照組（P<0.05）。結(jié)論 小兒清熱片聯(lián)合康復(fù)新液治療兒童口腔潰瘍的療效確切，能有效緩解患兒癥狀，迅速退熱，改善食欲，加速潰瘍愈合，減少?gòu)?fù)發(fā)，且安全性好。

Objective To investigate the clinical effect of Xiaoer Qingre Tablets combined with Kangfuxin Liquid in treatment of oral ulcer in children. Methods Children (86 cases) with oral ulcer in Beijing Children 's Hospital from January 2016 to January 2019 were randomly divided into control (43 cases) and treatment (43 cases) groups. Children in the control group were gargled administered with Kangfuxin Liquid after meals for 5 min, 10 mL/time, three times daily. Children in the treatment group were po administered with Xiaoer Qingre Tablets on the basis of the control group, 2 tablets/time, twice daily. Children in two groups were treated for 5 d. After treatment, the clinical efficacy was evaluated, and the main symptom scores, the antipyretic time and improvement time of appetite, the level of WBC and NEUT# in peripheral blood, the level of TNF-α, IL-6 and EGF in saliva in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 86.0% and 100.0% respectively, and there were differences between two groups (P < 0.05). After treatment, the scores of ulcer area, hyperemia and pain in two groups were significantly decreased (P < 0.05), and the scores in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the antipyretic time and improvement time of appetite in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the level of WBC and NEUT# in peripheral blood in two groups was significantly decreased (P < 0.05), and the level of TNF-α, IL-6 and EGF in saliva in two groups was significantly decreased (P < 0.05), and these indexes in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Xiaoer Qingre Tablets combined with Kangfuxin Liquid has definite curative effect in treatment of oral ulcer in children, can effectively relieve the symptoms, rapidly reduce fever, improve appetite, accelerate ulcer healing, reduce recurrence, and has good safety.

R985