+/CD8+水平均顯著升高(P<0.05);且治療組血清鋅、免疫因子水平較高(P<0.05)。治療后,兩組患兒超敏C反應(yīng)蛋白(hs-CRP)、腫瘤壞死因子(TNF)-α、白介素(IL)-6水平均顯著降低(P<0.05);并且治療組血清炎性因子水平降低較多(P<0.05)。結(jié)論 王氏保赤丸聯(lián)布拉氏酵母菌散治療小兒腹瀉具有較好的治療效果,可以改善臨床癥狀,降低炎癥因子水平,值得在臨床上推廣應(yīng)用。;Objective To study the effect of Wangshi Baochi Pills combined with Saccharomyces boulardii Sachets in treatment of infantile diarrhea. Methods Children (85 cases) with infantile diarrhea in Tianjin Children's Hospital from September 2016 to September 2019 were randomly divided into control (42 cases) and treatment (43 cases) groups. Children in the control group were po administered with Saccharomyces boulardii Sachets, 1 bag/time, once or twice daily to children below or above 3 years. Children in the treatment group were po administered with Wangshi Baochi Pills on the basis of the control group, once daily. And infants within 6 months:5 pills/time, 6 months to 2 years old:1 pill per month, and 2-6 years old:5 pills per half year. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the clinical symptom improvement time, serum zinc, levels of immune factors, and serum inflammatory factors in two groups were compared. Results After treatment, the effective rate of the treatment group (95.35%) was significantly higher than that (76.19%) of the control group (P < 0.05). After treatment, the recovery time of stool, body temperature, and disappearance time of vomiting in the treatment group were significantly shorter than those in the control group (P < 0.05). After treatment, serum zinc, IgA, IgG, and CD4+/CD8+ levels in two groups were significantly increased (P < 0.05). After treatment, serum zinc and immune factors in the treatment group were higher than those in the control group (P < 0.05). After treatment, the levels of TNF-α, IL-6, and hs-CRP in two groups were significantly decreased (P < 0.05). After treatment, levels of serum inflammatory factors in the treatment group were lower than those in the control group (P < 0.05). Conclusion Wangshi Baochi Pills combined with Saccharomyces boulardii Sachets has good clinical effect in treatment of infantile diarrhea, and can significantly improve clinical symptoms and reduce the level of inflammatory factors, which has a certain clinical application value."/>