目的 研究王氏保赤丸聯(lián)合布拉氏酵母菌散治療小兒腹瀉的臨床療效。方法 選取2016年9月-2019年9月來天津市兒童醫(yī)院治療的85例腹瀉患兒，將所有患兒隨機(jī)分為對照組（n=42）和治療組（n=43）。對照組患兒口服布拉氏酵母菌散，1袋/次，3歲以下兒童1次/d，3歲以上兒童2次/d；治療組患兒在對照組治療的基礎(chǔ)上口服王氏保赤丸，6個月以內(nèi)嬰兒：5丸/次，6個月至2周歲：每超過1個月加1丸，2~6歲：每超過半歲加5丸，1次/d。兩組患兒持續(xù)治療7 d。觀察兩組患者臨床療效，并比較治療前后兩組患者臨床癥狀改善時間、血清鋅、免疫因子水平、血清炎性因子水平變化情況。結(jié)果 治療后，對照組、治療組總有效率分別為76.19%、95.35%，治療組總有效率顯著較高（P<0.05）。治療后，治療組大便恢復(fù)時間、體溫恢復(fù)時間、嘔吐消失時間明顯短于對照組（P<0.05）。治療后，兩組患兒血清鋅、免疫球蛋白A（IgA）、免疫球蛋白G（IgG）、CD4⁺/CD8⁺水平均顯著升高（P<0.05）；且治療組血清鋅、免疫因子水平較高（P<0.05）。治療后，兩組患兒超敏C反應(yīng)蛋白（hs-CRP）、腫瘤壞死因子（TNF）-α、白介素（IL）-6水平均顯著降低（P<0.05）；并且治療組血清炎性因子水平降低較多（P<0.05）。結(jié)論 王氏保赤丸聯(lián)布拉氏酵母菌散治療小兒腹瀉具有較好的治療效果，可以改善臨床癥狀，降低炎癥因子水平，值得在臨床上推廣應(yīng)用。

Objective To study the effect of Wangshi Baochi Pills combined with Saccharomyces boulardii Sachets in treatment of infantile diarrhea. Methods Children (85 cases) with infantile diarrhea in Tianjin Children's Hospital from September 2016 to September 2019 were randomly divided into control (42 cases) and treatment (43 cases) groups. Children in the control group were po administered with Saccharomyces boulardii Sachets, 1 bag/time, once or twice daily to children below or above 3 years. Children in the treatment group were po administered with Wangshi Baochi Pills on the basis of the control group, once daily. And infants within 6 months:5 pills/time, 6 months to 2 years old:1 pill per month, and 2-6 years old:5 pills per half year. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the clinical symptom improvement time, serum zinc, levels of immune factors, and serum inflammatory factors in two groups were compared. Results After treatment, the effective rate of the treatment group (95.35%) was significantly higher than that (76.19%) of the control group (P < 0.05). After treatment, the recovery time of stool, body temperature, and disappearance time of vomiting in the treatment group were significantly shorter than those in the control group (P < 0.05). After treatment, serum zinc, IgA, IgG, and CD4⁺/CD8⁺ levels in two groups were significantly increased (P < 0.05). After treatment, serum zinc and immune factors in the treatment group were higher than those in the control group (P < 0.05). After treatment, the levels of TNF-α, IL-6, and hs-CRP in two groups were significantly decreased (P < 0.05). After treatment, levels of serum inflammatory factors in the treatment group were lower than those in the control group (P < 0.05). Conclusion Wangshi Baochi Pills combined with Saccharomyces boulardii Sachets has good clinical effect in treatment of infantile diarrhea, and can significantly improve clinical symptoms and reduce the level of inflammatory factors, which has a certain clinical application value.

R985