目的 探討暖宮孕子膠囊聯(lián)合注射用尿促性素治療排卵障礙性不孕癥的臨床療效。方法 選取2016年1月-2017年1月在南陽(yáng)市第二人民醫(yī)院治療的排卵障礙性不孕癥患者80例，根據(jù)用藥的差別分為對(duì)照組（40例）和治療組（40例）。對(duì)照組肌肉注射注射用尿促性素，起始75~150 IU/次，1次/d，一周后根據(jù)雌激素水平和卵泡發(fā)育情況調(diào)整劑量，增加至每日150~225 IU，卵泡成熟后肌內(nèi)注射絨促性素（HCG）10 000 IU，誘導(dǎo)排卵；治療組在對(duì)照組基礎(chǔ)上口服暖宮孕子膠囊，1.28 g/次，3次/d。兩組患者均治療3月。觀察兩組患者臨床療效，同時(shí)比較治療前后兩組患者子宮內(nèi)膜厚度、卵泡直徑，孕酮（P）、雌二醇（E2）、促卵泡成熟激素（FSH）和促黃體生成素（LH）水平，SAS和SDS評(píng)分及排卵率和妊娠率。結(jié)果 治療后，對(duì)照組和治療組臨床有效率分別為80.00%和97.50%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。經(jīng)治療，兩組患者子宮內(nèi)膜厚度、卵泡直徑均明顯增加（P<0.05），且以治療組比對(duì)照組增加更明顯（P<0.05）。治療后，兩組患者FSH、P、E2水平均明顯升高（P<0.05），而LH水平顯著下降（P<0.05），且治療組性激素水平明顯好于對(duì)照組（P<0.05）。經(jīng)治療，兩組患者SAS、SDS評(píng)分均明顯下降（P<0.05），且以治療組降低最明顯（P<0.05）。經(jīng)治療，對(duì)照組排卵率、妊娠率分別為67.5%、27.5%，分別顯著低于治療組的82.5%和42.5%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 暖宮孕子膠囊聯(lián)合注射用尿促性素治療排卵障礙性不孕癥可有效增加子宮內(nèi)膜厚度，緩解負(fù)面情緒，改善機(jī)體性激素水平，促進(jìn)排卵功能，提高妊娠率。

Objective To explore the clinical efficacy of Nuangong Yunzi Capsules combined with urogenin in treatment of ovulatory infertility. Methods Patients (80 cases) with ovulatory infertility in Nanyang Second General Hospital from January 2016 to January 2017 were divided into control (70 cases) and treatment (70 cases) groups based on different treatments. Patients in the control group were im administered with Menotrophin for injection, the initial dose was 75-150 IU/time, once daily, then the dosage was adjusted to 150-225 IU/d according to the estrogen level and follicular development after one week, and ovulation was induced by intramuscular injection of 10 000 IU HCG after follicular maturation. Patients in the treatment group were po administered with Nuangong Yunzi Capsules on the basis of the control group, 1.28 g/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and the endometrial thickness, follicular diameter, P, E2, FSH and LH levels, SAS and SDS scores, ovulation rate and pregnancy rate in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 80.00% and 97.50%, respectively, and there were differences between two groups (P < 0.05). After treatment, the endometrial thickness and follicular diameter in two groups were significantly increased (P < 0.05), and which in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the FSH, P and E2 levels in two groups were significantly increased (P < 0.05), but the LH levels were significantly decreased (P < 0.05), and these sex hormone levels in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the SAS and SDS scores in two groups were significantly decreased (P < 0.05), and which in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the ovulation rate and pregnancy rate in the control group were 67.5% and 27.5%, which were significantly lower than 82.5% and 42.5% in the treatment group, respectively, and there were differences between two groups (P < 0.05). Conclusion Nuangong Yunzi Capsules combined with urogenin in treatment of ovulatory infertility can effectively increase the thickness of endometrium, relieve negative emotions, improve the body's sex hormone level, promote ovulation function and increase pregnancy rate.

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