目的 分析2013-2018年南京大學(xué)醫(yī)學(xué)院附屬鼓樓醫(yī)院抑酸藥的使用情況及發(fā)展趨勢。方法 對2013-2018年南京大學(xué)醫(yī)學(xué)院附屬鼓樓醫(yī)院抑酸藥的用藥金額、用藥頻度（DDDs）、日均費(fèi)用（DDC）和藥品排序比（B/A）進(jìn)行統(tǒng)計(jì)分析。結(jié)果 質(zhì)子泵抑制劑的用藥金額遠(yuǎn)高于H2受體拮抗劑，注射用蘭索拉唑、注射用艾司奧美拉唑鈉、注射用泮托拉唑鈉、注射用奧美拉唑鈉和雷貝拉唑鈉腸溶片一直穩(wěn)居用藥金額的前5位。奧美拉唑腸溶膠囊和雷貝拉唑鈉腸溶片的DDDs穩(wěn)居前2位，2013-2018年除了西咪替丁注射液的DDC值上升外，其他藥品的DDC值都下降。奧美拉唑腸溶膠囊的B/A很高。結(jié)論 南京大學(xué)醫(yī)學(xué)院附屬鼓樓醫(yī)院抑酸藥的使用基本合理，質(zhì)子泵抑制劑是抑酸藥使用的主流。

Objective To study the use and development trend of acid inhibitors in Drum Tower Hospital Affiliated to Nanjing University Medical School from 2013 to 2018. Methods Consumption sum, defined daily doses (DDDs), defined daily cost (DDC), and drug sequence ratio (B/A) in Drum Tower Hospital Affiliated to Nanjing University Medical School from 2013 to 2018 were analyzed statistically. Results Consumption sum of proton pump inhibitors were far more than those of H2 receptor antagonists. Consumption sums of Lansoprazole for injection, Esomeprazole Sodium for injection, Pantoprazole Sodium for injection, Omeprazole Sodium for injection, and Sodium Rabeprazole Enteric-coated Tablets were consistently ranked the top 5. DDDs of Omeprazole Eenteric-coated Capsules and Rabeprazole Sodium Enteric-coated Tablets were in the top two places. DDC of Cimetidine Injection was increased from 2013 to 2018, but DDC of others were decreased. B/A of Omeprazole Enteric-coated Capsules was high. Conclusion The use of acid inhibitors in Drum Tower Hospital Affiliated to Nanjing University Medical School is basically reasonable. Proton pump inhibitors are the mainstream of acid inhibitors in the hospital.

R975