何首烏幾個(gè)世紀(jì)以來(lái)一直被用作補(bǔ)益良藥，在《中國(guó)藥典》中有兩種藥物形式，即生首烏和制首烏。但是，在體內(nèi)外甚至臨床使用中，兩種藥物形式都可能導(dǎo)致藥物誘導(dǎo)的肝損傷。何首烏相關(guān)的肝毒性正成為一個(gè)安全問題，引起了學(xué)者的關(guān)注。何首烏引起的肝毒性具體表現(xiàn)在免疫應(yīng)激反應(yīng)、氧化應(yīng)激與線粒體功能紊亂和影響代謝酶的功能和表達(dá)。對(duì)何首烏肝毒性的作用機(jī)制進(jìn)行了總結(jié)和歸納，為臨床應(yīng)用及研究提供理論依據(jù)。

Polygonum multiflorum Thunb. has been a tonic medicine for over a thousand years. There are two drug forms, Polygoni Multiflori Radix and Polygoni Multiflori Radix Prapaerata in the Chinese Pharmacopoeia. But both drug forms could lead to drug-induced liver injury and even death in vitro, in vivo and in clinical settings. Hepatotoxicity associated with Ploygoni Multiflori Radix is becoming a safety issue, which has attracted the attention of scholars. Hepatotoxicity of Ploygoni Multiflori Radix in this includes immune stress response, oxidative stress, mitochondrial dysfunction, and affecting the function and expression of metabolic enzymes and so on. The mechanism of hepatotoxicity of Ploygoni Multiflori Radix is reviewed in this paper, in order to provide theoretical basis for clinical application and research.

R961

國(guó)家自然科學(xué)基金資助項(xiàng)目（81803726）