慢性阻塞性肺疾?。–OPD）是呼吸系統(tǒng)疾病中常見的疾病，可引起呼吸衰竭、肺源性心臟病、心力衰竭等嚴重疾病。噻托溴銨作為長效的抗膽堿制劑，現(xiàn)為臨床治療慢性阻塞性肺炎的常用藥物，其可通過擴張支氣管、抑制炎癥因子和抑制氣道重塑的作用機制，進而有效緩解支氣管痙攣、呼吸困難和降低炎癥反應。主要對噻托溴銨治療慢性阻塞性肺疾病的作用機制進行綜述。

Chronic obstructive pulmonary disease is the common disease of respiratory diseases, which can cause respiratory failure, pulmonary heart disease, heart failure, and other serious diseases. As a long-acting anticholine preparation, tiotropium bromide has commonly used in clinical treatment of chronic obstructive pulmonary disease. It can effectively relieve bronchospasm, dyspnea, and reduce inflammation by dilating bronchus, inhibiting inflammatory factor, and inhibiting airway remodeling. The mechanism of tiotropium bromide in treatment of COPD is reviewed in this paper.

R974

江蘇省藥學會–天晴（連云港）醫(yī)院藥學科研項目（Q2018070）