丙泊酚是最常用的靜脈麻醉藥物之一，丙泊酚靶控輸注（TCI）是結(jié)合丙泊酚藥動(dòng)學(xué)參數(shù)和預(yù)設(shè)血藥濃度來計(jì)算輸注速度，以達(dá)到血中穩(wěn)定的丙泊酚濃度。但是丙泊酚的吸收、分布、代謝和排泄過程中存在顯著個(gè)體差異，這成為影響TCI準(zhǔn)確性的最重要因素。闡述了丙泊酚在體內(nèi)過程研究的最新觀點(diǎn)，結(jié)合三款具有代表性丙泊酚藥動(dòng)學(xué)模型，進(jìn)一步揭示丙泊酚在體內(nèi)的分布和代謝規(guī)律，指導(dǎo)臨床醫(yī)生針對(duì)不同臨床情景制定丙泊酚的個(gè)體化應(yīng)用策略。

Propofol is one of the most commonly used intravenous anesthetics. Target-controlled infusion (TCI) is an infusion technique that combines the pharmacokinetic parameters of propofol and the expected blood concentration to calculate the infusion rate, in order to achieve a stable concentration of propofol in the blood. However, there are significant individual differences in the absorption, distribution, metabolism, and excretion of propofol between patients, which have become the most important factor affecting the accuracy of TCI. The latest viewpoints of propofol in vivo research are elaborated in this paper, and three representative models of propofol pharmacokinetics are combined to further reveal the distribution and metabolism of propofol in vivo, to guide clinicians to develop individualized application strategies of propofol for different clinical scenarios.

R969.1

國家自然科學(xué)基金資助項(xiàng)目（30972839）；黑龍江省科學(xué)技術(shù)計(jì)劃項(xiàng)目（GC12C305-5）