目的 回顧性調查河南省人民醫(yī)院住院患者使用注射用紅花黃色素的超說明書現狀，為臨床合理用藥提供參考。方法 隨機選取河南省人民醫(yī)院2018年1~12月使用注射用紅花黃色素的住院患者醫(yī)囑1 420例。參照藥品說明書，對適應癥、用法用量、用藥療程、配伍溶媒、聯合用藥等合理性進行分析。結果 1 420例醫(yī)囑中，1 293例存在不同程度的超說明書用藥情況，超說明書用藥發(fā)生率為91.06%，表現為超適應癥（61.76%）、超單次劑量（63.66%）、超用藥頻次（0.28%）、超療程（4.44%）、超溶媒量（22.39%）、配伍（0.42%）和溶媒選擇不當（12.82%）。結論 注射用紅花黃色素的超說明書用藥情況廣泛存在，建議盡快出臺中藥注射劑的相關政策，科學化管理，并加強監(jiān)測與管控，促進臨床合理用藥。

Objective To investigate the current status of off label medication of Safflor Yellow for injection for inpatients in Henan Provincal People's Hospital in 2018, and provide a reference for clinical rational drug use. Methods 1 420 Orders of inpatients who used Safflor Yellow for injection from January to December 2018 were selected. According to the drug instructions, the rationality of indications, dosage, medication course, compatible solvents, and combined medication were analyzed. Results There were 1 293 off label medication orders in 1 420 cases of prescription, and the incidence rate of off label medication was 91.06%, including over indication (61.76%), over single dose (63.66%), over frequency (0.28%), over course (4.44%), over solvent amounts (22.39%), compatibility (0.42%), and improper solvent(12.82%). Conclusion Safflor Yellow for injection is widely off label used in Henan Provincal People's Hospital. It is suggested that policies for traditional Chinese medicine injection should be issued as soon as possible, monitoring and control management should be strengthened to promote rational use of drugs.

R969.3