術(shù)后譫妄是一種常見的術(shù)后并發(fā)癥，主要表現(xiàn)為急性起病，注意力不集中，意識水平改變和思維紊亂，常見于老年患者。關(guān)節(jié)置換術(shù)以老年患者為主，手術(shù)創(chuàng)傷大，術(shù)后譫妄發(fā)生率高。目前針對術(shù)后譫妄的防治藥物主要有右美托咪定、帕瑞昔布鈉、抗精神病藥物和激素類。對老年患者關(guān)節(jié)置換術(shù)后譫妄的防治藥物進行綜述，為臨床麻醉提供參考。

Postoperative delirium is a common postoperative complication with the main manifestations of acute onset, inattention, altered level of consciousness, and disordered thinking, and it is commonly seen in elderly patients. Joint replacement is mainly for elderly patients, but the surgery is traumatic, and postoperative delirium has a high incidence. At present, the main prevention and treatment drugs for postoperative delirium are dexmedetomidine, parecoxib sodium, antipsychotic drugs, and hormones. Drugs in prevention and treatment of postoperative delirium after joint replacement in the elderly patients are reviewed in this paper, to provide reference for clinical anesthesia.

R971

衛(wèi)生部國家臨床重點專科建設(shè)項目[財社（2011）170號]；重慶市醫(yī)學(xué)重點學(xué)科項目[渝衛(wèi)科教（2007）2]