長期以來，慢性阻塞性肺疾病（COPD）困擾著很多患者，由于其多樣性的臨床分型、復(fù)雜的作用機(jī)制，COPD目前尚缺少明確的生物標(biāo)志物用于早期診斷、干預(yù)和治療。對(duì)臨床分型和生物標(biāo)志物的準(zhǔn)確分析能夠有效提示疾病的發(fā)展進(jìn)程，指導(dǎo)臨床用藥，進(jìn)行精準(zhǔn)治療。對(duì)近年來報(bào)道的慢性阻塞性肺病的臨床分型和生物標(biāo)志物進(jìn)行綜述，期望為基礎(chǔ)研究、臨床診斷治療提供參考依據(jù)和指導(dǎo)作用。

Chronic obstructive pulmonary disease (COPD) plagues many patients for a long time, due to its diverse clinical classification and complex mechanism. There are still few clear biomarkers for early diagnosis, intervention and treatment of chronic obstructive pulmonary disease. Accurate analysis of clinical typing and biomarkers can effectively prompt the development process of the disease, guide clinical medication, and perform precise treatment. The types and biomarkers of chronic obstructive pulmonary disease reported in recent years are reviewed in this article, hoping to provide reference and guidance for basic research, clinical diagnosis, and treatment.

R974

天津市衛(wèi)健委中醫(yī)中西醫(yī)綜合科研項(xiàng)目（2019126）