帕金森病是常見的神經(jīng)系統(tǒng)變性疾病，藥物治療仍是目前臨床上控制和緩解其癥狀的主要方法。多巴胺受體激動劑作為治療帕金森病的新型手段，不僅能在早期改善患者臨床癥狀，而且在晚期顯著延緩和減輕運(yùn)動并發(fā)癥，因此受到藥物研發(fā)人員越來越多的關(guān)注。持續(xù)、穩(wěn)定的多巴胺受體刺激是控制帕金森病的有效手段，基于此理論，多巴胺受體激動劑緩釋制劑發(fā)展迅速，主要對其緩釋劑型及研究進(jìn)展進(jìn)行綜述。

Parkinson’s disease is a common neurodegenerative disease. At present, drug therapy is still the main method to control and relieve its symptoms in clinic. As a new treatment for Parkinson’s disease, dopamine receptor agonists can not only improve the clinical symptoms of patients in the early stage, but also significantly delay and attenuates motor complications in advanced stage of Parkinson’s disease, which has attracted more and more attention of drug researchers. Continuous dopamine-receptor stimulation is an effective therapy to control Parkinson’s disease. Based on this theory, the sustained-release systems of dopamine receptor agonist have developed rapidly. The research progress on dopamine receptor agonists sustained-release preparation is reviewed in this paper.

R971