目的 探討抑亢丸聯(lián)合丙硫氧嘧啶治療甲狀腺功能亢進(jìn)癥的臨床療效。方法 選取2018年1月-2020年1月在駐馬店市中心醫(yī)院治療的甲狀腺功能亢進(jìn)癥患者86例，隨機(jī)分為對(duì)照組（43例）和治療組（43例）。對(duì)照組口服丙硫氧嘧啶片，初始劑量100 mg/次，3次/d，服用半個(gè)月后，根據(jù)甲狀腺功能指標(biāo)調(diào)整劑量為50 mg/次，3次/d。治療組在對(duì)照組基礎(chǔ)上口服抑亢丸，6 g/次，2次/d。兩組均連續(xù)治療2個(gè)月。觀察兩組患者臨床療效，同時(shí)比較治療前后兩組患者血清游離三碘甲腺原氨酸（FT3）、血清游離甲狀腺素（FT4）、三碘甲狀腺原氨酸（T3）和甲狀腺素（T4）水平，及不良反應(yīng)情況。結(jié)果 治療后，對(duì)照組和治療組臨床有效率分別為76.74%和93.02%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者FT3、FT4、T3、T4水平均顯著降低（P<0.05），且治療組顯著低于對(duì)照組（P<0.05）。治療期間，對(duì)照組患者藥物不良反應(yīng)發(fā)生率為46.51%，顯著高于治療組的16.28%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 抑亢丸聯(lián)合丙硫氧嘧啶治療甲狀腺功能亢進(jìn)可明顯改善臨床癥狀，促進(jìn)甲狀腺功能指標(biāo)的恢復(fù)，且不良反應(yīng)低。

Objective To investigate the curative effect of Yikang Pills combined with prothiouracil in treatment of hyperthyroidism. Methods Patients (86 cases) with hyperthyroidism in Zhumadian Central Hospital from January 2018 to January 2020 were randomly divided into control (43 cases) and treatment (43 cases) groups. Patients in the control group were po administered with Propylthiouracil Tablets, the initial dose was 100 mg/time, three times daily, and the dose was adjusted to 50 mg/time after 15 d, three times daily. Patients in the treatment group were po administered with Yikang Pills on the basis of the control group, 6 g/time, twice daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacy was evaluated, and the levels of FT3, FT4, T3 and T4, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 76.74% and 93.02% respectively, and there were differences between two groups (P < 0.05). After treatment, the levels of FT3, FT4, T3 and T4 in two groups were significantly decreased (P < 0.05), and these thyroid function indexes in the treatment group were significantly lower than those in the control group (P < 0.05). During the treatment, the adverse reactions rate in the control group was 46.51%, which was significantly higher than 16.28% in treatment the group, with significant difference between two groups (P < 0.05). Conclusion Yikang Pills combined with propylthiouracil in treatment of hyperthyroidism can significantly improve the clinical symptoms, promote the recovery of thyroid function with less adverse reactions.

R977

河南省科技研發(fā)專項(xiàng)項(xiàng)目（172102310044）