目的 探討金剛藤膠囊聯(lián)合注射用頭孢美唑鈉治療慢性盆腔炎的臨床療效。方法 選取2018年11月-2019年10月在鄭州大學(xué)醫(yī)院進行治療的108例慢性盆腔炎患者為研究對象，根據(jù)用藥差別分為對照組（54例）和治療組（54例）。對照組患者靜脈滴注注射用頭孢美唑鈉，1.0 g加入生理鹽水100 mL，2次/d；治療組患者在對照組治療基礎(chǔ)上口服金剛藤膠囊，2 g/次，3次/d。兩組均經(jīng)2周治療后進行效果比較。比較兩組的臨床療效，觀察兩組治療前后中醫(yī)癥候積分、WHOQOL-100評分、血清學(xué)指標和子宮動脈血流動力參數(shù)的變化情況。結(jié)果 治療后，治療組總有效率是98.15%顯著高于對照組的85.19%（P<0.05）。經(jīng)治療，兩組中醫(yī)癥候積分均較治療前顯著降低，而WHOQOL-100評分均增高（P<0.05）；治療后，治療組中醫(yī)癥候積分低于對照組，而WHOQOL-100評分高于對照組（P<0.05）。經(jīng)治療，兩組血清C反應(yīng)蛋白（CRP）、粒細胞-巨噬細胞集落刺激因子（GM-CSF）、降鈣素原（PCT）、血紅素氧合酶1（HO-1）、單核細胞趨化蛋白-1（MCP-1）水平均較治療前顯著降低（P<0.05）；且治療后治療組這些血清學(xué)指標顯著低于對照組（P<0.05）。經(jīng)治療，兩組子宮動脈血流搏動指數(shù)（PI）、阻力指數(shù)（RI）、收縮期峰值血流速度（PSV）均顯著改善（P<0.05），且以治療組改善更顯著（P<0.05）。結(jié)論 金剛藤膠囊聯(lián)合注射用頭孢美唑鈉治療慢性盆腔炎具有較好的臨床療效，可有效改善患者臨床癥狀，降低機體炎癥反應(yīng)，有利于改善子宮動脈血流動力學(xué)指標，提高患者生活質(zhì)量，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical efficacy of Jingangteng CapsuleS combined with Cefmetazole Sodium for injection in treatment of chronic pelvic inflammation. Methods 108 Patients with chronic pelvic inflammation who were treated in Zhengzhou University Hospital from November 2018 to October 2019 were selected as the research objects, and they were divided into control group (54 cases) and treatment group (54 cases) according to the difference of medication. The control group was iv administered with Cefmetazole Sodium for injection, 1.0 g was added to normal saline 100 mL, twice daily. The treatment group was po administered with Jingangteng Capsules on the basis of the control group, 2 g/time, three times daily. The two groups were compared after 2 weeks of treatment. The clinical efficacy of the two groups was compared, and the changes of TCM syndrome score, WHOQOL-100 score, serological indexes and uterine artery hemodynamic parameters were observed before and after treatment in the two groups. Results After treatment, the total effective rate of the treatment group was 98.15%, significantly higher than that of the control group (85.19%) (P < 0.05). After treatment, the scores of TCM syndromes in both groups were significantly lower than before treatment, while WHOQOL-100 score was increased (P < 0.05). After treatment, the scores of TCM syndromes in the treatment group were lower than those in the control group, while the WHOQOL-100 score was higher than that in the control group (P < 0.05). After treatment, the serum levels of C-reactive protein (CRP), granulocyte-macrophage colony stimulating factor (GM-CSF), procalcitonin (PCT), heme oxygenase 1 (HO-1) and monocyte chemotactic protein-1 (McP-1) in two groups were significantly lower than before treatment (P < 0.05). After treatment, the serological indexes of the treatment group were significantly lower than those of the control group (P < 0.05). After treatment, the uterine artery pulse index (PI), resistance index (RI) and systolic peak blood flow velocity (PSV) of the two groups were significantly improved (P < 0.05), and the improvement was more significant in the treatment group (P < 0.05). Conclusion Jingangteng Capsules combined with cefmetazole sodium has good clinical effect in treatment of chronic pelvic inflammation, and can effectively improve the patients' clinical symptoms, reduce the body's inflammatory response, and also can improve the uterine arterial blood flow mechanics indexes, and improve the patients' life quality, which has a certain clinical application value.

R984

河南省中醫(yī)藥科學(xué)研究專項課題（2016zy2094）