[關(guān)鍵詞]
[摘要]
目的 研究銀杏葉片聯(lián)合阿替洛爾片治療急性心肌梗死的臨床療效。方法 選取2018年1月-2019年6月在天津市第三中心醫(yī)院分院治療的120例急性心肌梗死患者,將所有患者隨機(jī)分為對(duì)照組和治療組,每組各60例。對(duì)照組口服阿替洛爾片,6.25~12.5 mg/次,2次/d。治療組在對(duì)照組基礎(chǔ)上口服銀杏葉片,2片/次,3次/d。兩組患者持續(xù)治療14 d。觀察兩組患者臨床療效,對(duì)比兩組的心功能指標(biāo)和血清生化指標(biāo)水平。結(jié)果 治療后,對(duì)照組和治療組的總有效率分別為81.67%、95.00%,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組患者左心室舒張末期內(nèi)徑(LVEDD)顯著降低,左心室射血分?jǐn)?shù)(LVEF)和左心室高峰充盈率(LVPFR)顯著升高(P<0.05),且治療組心功能指標(biāo)改善較明顯(P<0.05)。治療后,兩組血清白細(xì)胞介素-6(IL-6)、N-末端腦鈉肽前體(NT-proBNP)、肌酸激酶(CK)和內(nèi)皮素-1(ET-1)水平均顯著降低(P<0.05);并且治療組血清生化指標(biāo)水平降低較明顯(P<0.05)。結(jié)論 銀杏葉片聯(lián)合阿替洛爾片治療急性心肌梗死具有較好的治療效果,能夠改善心肌功能,降低血清生化指標(biāo)水平。
[Key word]
[Abstract]
Objective To study the clinical effect of Yinxingye Tablets combined with Atenolol Tablets in treatment of acute myocardial infarction. Methods Patients (120 cases) with acute myocardial infarction in Branch of Tianjin Third Central Hospital from January 2018 to June 2019 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Atenolol Tablets, 6.25-12.5 mg/time, twice daily. Patients in the treatment group were po administered with Yinxingye Tablets on the basis of the control group, 2 tablets/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and cardiac function index and biochemical indexes levels in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.67% and 95.00%, respectively, and there was difference between two groups (P < 0.05). After treatment, the LVEDD in two groups was significantly decreased, but the LVEF and LVPFR in two groups were significantly increased (P < 0.05). And the cardiac function indexes in the treatment group were significantly improved than those in the control group (P < 0.05). After treatment, the serum levels of IL-6, NT proBNP, CK, and ET-1 in the two groups were significantly decreased (P < 0.05), and the biochemical indexes in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Yinxingye Tablets combined with Atenolol Tablets has clinical curative effect in treatment of acute myocardial infarction, can improve myocardial function, and reduce the serum level of biochemical indexes.
[中圖分類號(hào)]
R972
[基金項(xiàng)目]