目的 探討小兒雙清顆粒聯(lián)合頭孢西丁治療小兒急性上呼吸道感染的臨床療效。方法 選取2018年8月-2019年8月在天津市泰達(dá)醫(yī)院就診的急性上呼吸道感染患兒150例，根據(jù)用藥的差別分為對照組（75例）和治療組（75例）。對照組靜脈滴注注射用頭孢西丁鈉，13.3~26.7 mg/kg加入生理鹽水100 mL；治療組在對照組基礎(chǔ)上口服小兒雙清顆粒，1~3歲，2~3 g/次，4~6歲，3~4 g/次，>6歲，4~5 g/次，3次/d。兩組患兒均治療7 d。觀察兩組患者臨床療效，同時比較治療前后兩組患兒臨床癥狀消失時間，及血清超敏C反應(yīng)蛋白（hs-CRP）、降鈣素原（PCT）、白細(xì)胞介素-6（IL-6）、IL-1β、腫瘤壞死因子-α（TNF-α）水平。結(jié)果 治療后，對照組和治療組臨床有效率分別為82.67%和97.33%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，治療組患者癥狀消失時間明顯早于對照組（P<0.05）。治療后，兩組患者血清hs-CRP、PCT、IL-6、IL-1β、TNF-α水平均明顯降低（P<0.05），且治療組患者明顯低于對照組（P<0.05）。結(jié)論 小兒雙清顆粒聯(lián)合頭孢西丁鈉治療小兒急性上呼吸道感染，能顯著改善臨床癥狀，降低機(jī)體炎癥因子表達(dá)，具有一定的臨床推廣應(yīng)用價值。

Objective To explore the clinical effect of Xiaoer Shuangqing Granules combined with cefoxitin in treatment of acute upper respiratory tract infection in children. Methods Children (65 cases) with acute upper respiratory tract infection in Tianjin TEDA Hospital from August 2018 to August 2019 were randomly divided into control (75 cases) and treatment (75 cases) groups. Children in the control group were iv administered with Cefoxitin Sodium for injection, 13.3-26.7 mg/kg added into normal saline 100 mL. Children in the treatment group were po administered with Xiaoer Shuangqing Granules on the basis of the control group, 2-3 g/time for 1-3 years old, 3-4 g/time for 4-6 years old, 4-5 g/time for more than 6 years old, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the disappearance time of clinical symptoms, and the serum levels of hs-CRP, PCT, IL-6, IL-1β and TNF-α in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 82.67% and 97.33% respectively, and there were differences between two groups (P < 0.05). After treatment, the disappearance time of clinical symptoms in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the serum levels of hs-CRP, PCT, IL-6, IL-1β and TNF-α in two groups were significantly decreased (P < 0.05), and these serological indexes levels in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Xiaoer Shuangqing Granules combined with cefoxitin in treatment of acute upper respiratory tract infection in children can significantly improve the clinical symptoms, decrease the expression of inflammatory factors, which has a certain clinical application value.

R974