目的 對2017-2019年南陽市第一人民醫(yī)院感染病原菌的分布及耐藥性進(jìn)行分析。方法 采用回顧性分析方法對2017-2019年南陽市第一人民醫(yī)院感染病原菌的分布及耐藥性進(jìn)行分析。結(jié)果 2017-2019年298例患者醫(yī)院感染共有319份樣本，其中以痰液居多，構(gòu)成比為44.83%，2017-2019年構(gòu)成比分別為46.15%、46.23%、42.20%。其次為尿液，構(gòu)成比為32.92%。共檢測出348株病原菌，以革蘭陰性菌為主，共242株，構(gòu)成比為69.54%，主要為銅綠假單胞菌和大腸埃希菌；革蘭陽性菌共102株，構(gòu)成比為32.18%，主要為金黃色葡萄球菌，共65株，構(gòu)成比為18.68%。銅綠假單胞菌、大腸埃希菌對氨芐西林、環(huán)丙沙星、美羅培南和青霉素的耐藥性較高，耐藥率均在72.73%~92.68%。金黃色葡萄球菌對阿米卡星、慶大霉素、美羅培南和呋喃妥因的耐藥性較高，耐藥率均在75.00%以上，特別是對美羅培南的耐藥率，2017年為100.00%。結(jié)論 2017-2019年南陽市第一人民醫(yī)院感染患者的病原菌以革蘭陰性菌為主，主要病原菌對氨芐西林、環(huán)丙沙星、美羅培南抗生素的耐藥性均較高。

Objective To analyze the distribution and drug resistance of pathogenic bacteria in Nanyang First People's Hospital from 2017 to 2019. Methods A retrospective survey was conducted to analyze the distribution and drug resistance of pathogenic bacteria in Nanyang First People's Hospital from 2017 to 2019. Results A total of 298 patients with hospital infections from 2017 to 2019 had a total of 319 samples, of which the majority were sputum samples with the constituent ratio of 44.83%. And the constituent ratio of sputum samples from 2017 to 2019 were 46.15%, 46.23%, and 42.20%, respectively. A total of 348 strains of pathogenic bacteria were detected, Gram-negative bacteria were 242 strains (69.54%), and main of them were Pseudomonas aeruginosa and Escherichia coli. Gram-positive bacteria were 102 strains (32.18%), and main of them were Staphylococcus aureus (65 strains) with the constituent ratio of 18.68%. P. aeruginosa and E. coli had high drug resistance against ampicillin, ciprofloxacin, meropenem, and penicillin, and the drug resistance rate were 72.73%-92.68%. S. aureus had high drug resistance against amikacin, gentamycin, meropenem, and nitrofurantoin, and the drug resistance rate were above 75.00%. Especially the drug resistance rate against meropenem was 100.00% in 2017. Conclusion From 2017 to 2019, the pathogenic bacteria in Nanyang First People's Hospital from 2017 to 2019 are mainly Gram-negative bacteria, and the main pathogenic bacteria are highly resistant to antibacterial drugs such as ampicillin, ciprofloxacin, and meropenem.

R978.1

河南省衛(wèi)計(jì)委科研項(xiàng)目（201602389）