目的 觀察消乳散結膠囊聯(lián)合他莫昔芬治療乳腺增生癥的臨床效果。方法 選擇2017年2月—2019年4月在鄭州大學第三附屬醫(yī)院治療的乳腺增生癥患者77例，隨機分為對照組（38例）和治療組（39例）。對照組口服枸櫞酸他莫昔芬片，1片/次，2次/d。治療組在對照組基礎上口服消乳散結膠囊，3粒/次，3次/d。兩組患者連續(xù)治療3個月。觀察兩組患者臨床療效，同時比較治療前后兩組患者性激素水平和臨床癥狀改善情況。結果 治療后，對照組和治療組臨床有效率分別為71.05%、92.31%，兩組比較差異有統(tǒng)計學意義（P<0.05）。治療后，兩組患者孕酮（P）和卵泡刺激素（FSH）水平均明顯升高（P<0.05），而黃體生成激素（LH）和雌二醇（E2）水平均顯著降低（P<0.05），且治療組P、FSH、LH和E2水平明顯比對照組好（P<0.05）。治療后，兩組腫塊最大徑和疼痛程度均明顯降低（P<0.05），且治療組明顯比對照組小（P<0.05）。結論 消乳散結膠囊聯(lián)合他莫昔芬治療乳腺增生癥，可明顯緩解乳房脹痛，縮小乳腺腫塊，改善性激素水平，臨床效果較好。

Objective To observe the clinical effect of Xiaoru Sanjie Capsules combined with tamoxifen in treatment of mammary hyperplasia. Methods Patients (77 cases) with mammary hyperplasia in the Third Affiliated Hospital of Zhengzhou University from February 2017 to April 2019 were randomly divided into control (38 cases) and treatment (39 cases) groups. Patients in the control group were po administered with Tamoxifen Citrate Tablets, 1 tablet/time, twice daily. Patients in the treatment group were po administered with Xiaoru Sanjie Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and the sex hormone levels and the improvement of clinical symptoms in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 71.05% and 92.31%, respectively, and there were differences between two groups (P<0.05). After treatment, the levels of P and FSH in two groups were significantly increased (P<0.05), but the levels of LH and E2 were significantly decreased (P<0.05), and the sex hormone levels in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the maximum diameter of the mass and VAS score in two groups were significantly decreased (P<0.05), and these indexes in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Xiaoru Sanjie Capsules combined with tamoxifen in treatment of mammary hyperplasia can obviously relieve breast tenderness, reduce breast lumps, improve sex hormone levels, which has a good clinical effect.

R984

河南省醫(yī)學科技攻關計劃普通項目（201503111）