目的 探討平消膠囊聯(lián)合左甲狀腺素鈉片治療結(jié)節(jié)性甲狀腺腫的臨床療效。方法 選取2017年10月—2019年12月焦作市人民醫(yī)院收治的300例結(jié)節(jié)性甲狀腺腫患者作為研究對(duì)象，按照隨機(jī)數(shù)字表法將300例患者分為對(duì)照組和治療組，每組各150例。對(duì)照組口服左甲狀腺素鈉片，50 μg/次，1次/d。治療組在對(duì)照組患者治療的基礎(chǔ)上口服平消膠囊，1.5 g/次，3次/d。兩組患者連續(xù)治療3個(gè)月。觀察兩組的臨床療效，比較兩組的結(jié)節(jié)直徑、血清甲狀腺激素和血清因子水平。結(jié)果 治療后，治療組的總有效率為94.00%，明顯高于對(duì)照組的87.33%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組的結(jié)節(jié)直徑顯著縮?。?i>P<0.05）；治療后，治療組的結(jié)節(jié)直徑明顯低于對(duì)照組（P<0.05）。治療后，兩組的促甲狀腺激素（TSH）水平顯著降低，且治療組TSH水平降低的更明顯（P<0.05），治療后兩組總?cè)饧紫僭彼幔═T3）、游離型T3（FT3）水平無(wú)顯著差異。治療后，兩組的血管內(nèi)皮生長(zhǎng)因子（VEGF）、轉(zhuǎn)化生長(zhǎng)因子-β₁（TGF-β₁）水平明顯降低（P<0.05）；治療后，治療組的VEGF、TGF-β₁水平明顯低于對(duì)照組（P<0.05）。結(jié)論 平消膠囊聯(lián)合左甲狀腺素鈉片可提高結(jié)節(jié)性甲狀腺腫的療效，促進(jìn)結(jié)節(jié)直徑縮小，調(diào)節(jié)VEGF、TGF-β₁水平。

Objective To explore the clinical effect of Pingxiao Capsules combined with Levothyroxine Sodium Tablets in treatment of nodular goiter. Methods Patients (300 cases) with nodular goiter in Jiaozuo People's Hospital from October 2017 to December 2019 were randomly divided into control and treatment groups, and each group had 150 cases. Patients in the control group were po administered with Levothyroxine Sodium Tablets, 50 μg/time, once daily. Patients in the treatment group were po administered with Pingxiao Capsules on the basis of the control group, 1.5 g/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and nodule diameter, the serum levels of thyroid hormone and serum factors were compared. Results After treatment, the total effective rate of the treatment group was 94.00%, which was significantly higher than that of the control group (87.33%), and there was difference between two groups (P<0.05). After treatment, the diameter of nodules in two groups was significantly reduced (P<0.05). And after treatment, the diameter of nodules in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, the levels of TSH in two groups were significantly decreased, and the level of TSH in the treatment group was more significantly reduced (P<0.05). But after treatment, there was no significant difference in the levels of TT3 and FT3 between two groups. After treatment, the levels of VEGF and TGF-β₁ in two groups were significantly decreased (P<0.05). After treatment, the levels of VEGF and TGF-β₁ in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Pingxiao Capsules combined with Levothyroxine Sodium Tablets can improve the curative effect of nodular goiter, promote the reduction of nodule diameter, and regulate the levels of VEGF and TGF-β₁.

R984

河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃聯(lián)合共建項(xiàng)目（2018020852）