1(TGF-β1)的水平,對患者的病情嚴(yán)重程度采用前列腺癥狀評分(IPSS)進行評估。結(jié)果 治療后,治療組患者總有效率為93.18%,對照組總有效率為77.27%,兩組比較差異有統(tǒng)計學(xué)意義(P<0.05)。治療后,兩組的殘余尿量、前列腺體積顯著降低,最大尿流率顯著提高(P<0.05);治療后,治療組的殘余尿量、前列腺體積低于對照組,最大尿流率高于對照組(P<0.05)。治療后,兩組的tPSA、IGF-1、TGF-β1顯著降低(P<0.05);治療后治療組的tPSA、IGF-1、TGF-β1低于對照組(P<0.05)。治療后,兩組的IPSS評分顯著降低,治療組的IPSS評分較對照組降低的更明顯,差異有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 寧泌泰膠囊聯(lián)合鹽酸坦索羅辛緩釋膠囊治療良性前列腺增生癥具有較好的臨床療效,可減輕臨床癥狀,調(diào)節(jié)tPSA、IGF-1、TGF-β1的分泌。;Objective To explore the clinical effect of Ningmitai Capsules combined with Tamsulosin Hydrochloride Sustained Release Capsules in treatment of benign prostatic hyperplasia. Methods Patients (88 cases) with benign prostatic hyperplasia in Zhengzhou Yihe Hospital Affiliated to Henan University from June 2018 to March 2020 were randomly divided into control and treatment groups, and each group had 44 cases. Patients in the control group were po administered with Tamsulosin Hydrochloride Sustained Release Capsules, 0.2 mg/time, once daily. Patients in the treatment group were po administered with Ningmitai Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and residual urine volume, prostate volume, maximum urine flow rate, and the levels of tPSA, IGF-1, and TGF-β1 in two groups were compared. The severity of the disease in two groups was evaluated by IPSS scores. Results After treatment, the total effective rate of the treatment group was 93.18%, and that of the control group was 77.27%, and there was difference between two groups (P<0.05). After treatment, the residual urine volume and prostate volume of two groups were significantly reduced, and the maximum urinary flow rate was significantly increased (P<0.05). After treatment, the residual urine volume and prostate volume of the treatment group were lower than those of the control group, and the maximum urinary flow rate of the treatment group was higher than that of the control group (P<0.05). After treatment, the levels of tPSA, IGF-1, and TGF-β1 in two groups were significantly decreased (P<0.05). After treatment, the levels of tPSA, IGF-1, and TGF-β1 in the treatment group were lower than those in the control group (P<0.05). After treatment, the IPSS score of two groups was significantly decreased, and the IPSS score of the treatment group was more significantly lower than that of the control group (P<0.05). Conclusion Ningmitai Capsules combined with Tamsulosin Hydrochloride Sustained Release Capsules has clinical curative effect in treatment of benign prostatic hyperplasia, can relieve clinical symptoms, and regulate the secretion of tPSA, IGF-1 and TGF-β1, which has good clinical application value."/>