目的 探討婦科再造膠囊聯合地屈孕酮片治療月經不調的臨床療效。方法 選取2019年5月—2020年5月在南陽市臥龍區(qū)婦幼保健院進行診治的98例月經不調患者為研究對象，根據就診的順序分為對照組和治療組，每組各49例。對照組口服地屈孕酮片，10 mg/次，2次/d；治療組在對照組基礎上口服婦科再造膠囊，6粒/次，2次/d。兩組均連續(xù)治療1個月經周期。觀察兩組的臨床療效，比較兩組相關評分、臨床癥狀改善時間、性激素水平。結果 經治療，治療組總有效率97.96%顯著高于對照組的81.63%（P<0.05）。經治療，兩組QOL評分、HPS評分、KPS評分均較治療前顯著升高，而PBAC評分均顯著下降（P<0.05）；治療后，治療組這些相關評分改善優(yōu)于對照組（P<0.05）。經治療，治療組在腰骶酸痛、少氣懶言、五心煩熱、神疲乏力等癥狀改善時間上均顯著短于對照組（P<0.05）。經治療，兩組血清卵泡生成激素（FSH）、黃體生成激素（LH）均較治療前顯著降低，而雌二醇（E₂）水平均顯著升高（P<0.05）；且治療后，治療組性激素水平改善優(yōu)于對照組（P<0.05）。結論 婦科再造膠囊聯合地屈孕酮治療月經不調具有較好的臨床療效，可有效改善患者臨床癥狀，改善性激素水平，具有一定的臨床推廣應用價值。

Objective To investigate the clinical effect of Fuke Zaizao Capsules combined with dydrogesterone in treatment of irregular menstruation. Methods 98 Patients with irregular menstruation who were treated in Nanyang Wolong District Maternal and Child Health Hospital from May 2019 to May 2020 were selected as the research objects, and they were divided into control group and treatment group according to the order of treatment, with 49 cases in each group. The control group was po administered with Dydrogesterone Tablets, 10 mg/time, twice daily. The treatment group was po administered with Fuke Zaizao Capsules on the basis of the control group, 6 grains/time, twice daily. Both groups were treated continuously for one menstrual cycle. The clinical efficacy of the two groups was observed, and the relevant scores, improvement time of clinical symptoms and sex hormone levels of the two groups were compared. Results After treatment, the total effective rate of 97.96% in the treatment group was significantly higher than that of 81.63% in the control group (P<0.05). After treatment, QOL score, HPS score and KPS score in both groups were significantly increased compared with those before treatment, while PBAC score was significantly decreased (P<0.05). After treatment, these scores improved better in the treatment group than in the control group (P<0.05). After treatment, the improvement time of lumbosacral soreness, little energy and lazy speech, five distractibility and heat, mental fatigue and other symptoms in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment, serum follicle-generating hormone (FSH) and luteinizing hormone (LH) in the two groups were significantly lower than that before treatment, while the levels of estradiol (E₂) were significantly higher (P<0.05). After treatment, the improvement of sex hormone level in the treatment group was better than that in the control group (P<0.05). Conclusion Fuke Zaizao Capsules combined with dydrogesterone has a good clinical effect in treatment of irregular menstruation, and can effectively improve the clinical symptoms of patients, improve the level of sex hormones, which has certain clinical application value.

R984

河南省科技計劃發(fā)展項目（162102310231）