目的 研究齒痛消炎靈顆粒聯(lián)合奧硝唑片治療智齒冠周炎的臨床療效。方法 選取2018年3月—2020年3月在焦作煤業(yè)（集團(tuán)）有限責(zé)任公司中央醫(yī)院治療的120例智齒冠周炎患者（患牙141顆），隨機(jī)分為對(duì)照組（60例，患牙70顆）和治療組（60例，患牙71顆）。對(duì)照組患者給予奧硝唑片，1片/次（研磨成粉，制成糊狀膏體，采用牙周探針涂入盲袋內(nèi)），1次/d。治療組在對(duì)照組基礎(chǔ)上口服齒痛消炎靈顆粒，1袋/次，3次/d。兩組患者接受治療時(shí)間為10 d。觀(guān)察兩組患者臨床療效，比較兩組的臨床癥狀緩解時(shí)間、牙周指標(biāo)、口腔健康影響程度量表（OHIP-14）評(píng)分和視覺(jué)模擬評(píng)分法（VAS）評(píng)分、齦溝液炎性因子水平。結(jié)果 治療后，治療組總有效率（96.67%）顯著高于對(duì)照組（78.33%）（P<0.05）。治療后，治療組牙齦紅腫、牙齦疼痛、牙齦出血消失時(shí)間明顯短于對(duì)照組（P<0.05）。治療后，兩組牙齦指數(shù)（GI）、牙菌斑指數(shù)（PLI）、牙周袋深度（PD）和齦溝出血指數(shù)（SBI）顯著降低（P<0.05）；且治療組牙周指標(biāo)水平降低較明顯（P<0.05）。治療后，兩組OHIP-14評(píng)分和VAS評(píng)分均顯著降低（P<0.05）；且治療組OHIP-14評(píng)分和VAS評(píng)分降低較明顯（P<0.05）。治療后，兩組齦溝液白細(xì)胞介素-1β（IL-1β）和超敏C-反應(yīng)蛋白（hs-CRP）水平顯著降低（P<0.05）；且治療組IL-1β和hs-CRP水平較低較明顯（P<0.05）。結(jié)論 齒痛消炎靈顆粒聯(lián)合奧硝唑片治療智齒冠周炎具有較好的治療效果，可改善臨床癥狀，降低患者齦溝液炎性因子水平。

Objective To study the effect of Chitong Xiaoyanling Granules combined with Ornidazole Tablets in treatment of pericoronitis. Methods Patients (120 cases, 141 teeth) with pericoronitis in Central Hospital of Jiaozuo Coal Industry (Group) Co., Ltd., from March 2018 to March 2020 were randomly divided into the control group (60 cases, 70 teeth) and the treatment group (60 cases, 71 teeth). Patients in the control group were given Ornidazole Tablets, 1 tablet/time (The drug was ground into powder and made into paste, which was applied into the blind bag by the periodontal probe), once daily. Patients in the treatment group were po administered with Chitong Xiaoyanling Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacies were evaluated, and the clinical symptom relief time, the periodontal index, the OHIP-14 score, the VAS score, the inflammatory factors in the gingival crevicular fluid of two groups were compared. Results After treatment, the total effective rate of the treatment group (96.67%) was significantly higher than that of the control group (78.33%) (P<0.05). After treatment, the disappearance times of gingival redness, gingival pain and gingival bleeding in the treatment group was significantly shorter than those in the control group (P<0.05). After treatment, the GI, PLI, PD, and SBI in two groups were significantly decreased (P<0.05), and the periodontal indexes in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the OHIP-14 score and the VAS score of two groups were significantly decreased (P<0.05), and the OHIP-14 score and the VAS score of the treatment group were significantly lower than those of the control group (P<0.05). After treatment, the levels of IL-1β and hs-CRP in the gingival crevicular fluid of two groups were significantly decreased (P<0.05), and the levels of IL-1β and hs-CRP in the gingival crevicular fluid of the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Chitong Xiaoyanling Granules combined with Ornidazole Tablets has clinical curative effect in treatment of pericoronitis, can improve the clinical symptoms, and reduce the level of inflammatory factors in gingival crevicular fluid.

R988.2

河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃省部共建項(xiàng)目（SB201901088）