目的 探討碘甘油聯(lián)合曲安奈德口腔軟膏治療口腔潰瘍的臨床療效。方法 選取2018年1月—2020年1月河南大學(xué)賽思口腔醫(yī)院進(jìn)行診治的116例口腔潰瘍患者為研究對象，根據(jù)就診順序分為對照組（58例）和治療組（58例）。對照組給予曲安奈德口腔軟膏，于餐后取約1 cm藥膏輕輕涂抹在病損表面，3次/d；治療組在對照組基礎(chǔ)上給予碘甘油，用棉簽蘸取少量涂于患處，3次/d。兩組均治療1周后進(jìn)行效果評價(jià)。結(jié)果 治療后，治療組總有效率是98.28%，顯著高于對照組的82.76%（P<0.05）。經(jīng)治療，治療組疼痛緩解時(shí)間和潰瘍面愈合時(shí)間顯著短于對照組（P<0.05）。經(jīng)治療，兩組患者SAS評分、VAS評分顯著降低（P<0.05），而QLQ-C30評分顯著升高（P<0.05）；治療后，治療組這些評分優(yōu)于對照組（P<0.05）。治療后，兩組血清C反應(yīng)蛋白（hs-CRP）、白細(xì)胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）水平顯著降低，而白細(xì)胞介素-2（IL-2）、表皮生長因子（EGF）水平顯著增高（P<0.05）；治療后治療組hs-CRP、IL-6、TNF-α低于對照組，而IL-2、EGF高于對照組（P<0.05）。結(jié)論 碘甘油聯(lián)合曲安奈德口腔軟膏治療口腔潰瘍可顯著改善患者臨床癥狀，抑制炎癥反應(yīng)，促進(jìn)病損愈合，有利于患者焦慮狀態(tài)及生活質(zhì)量的改善，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the clinical effect of Iodine Glycerol combined with Triamcinolone Acetonide Dental Paste in treatment of oral ulcer. Methods 116 Patients with oral ulcer in SATH Hospital of Stomatology Henan University from January 2018 to January 2020 were selected as the research objects, and they were divided into control group (58 cases) and treatment group (58 cases) according to the order of treatment. The control group was given Triamcinolone Acetonide Dental Paste. After eating, take about 1cm ointment and gently apply it on the damaged surface for 3 times daily. The treatment group was given Iodine Glycerol on the basis of the control group. A small amount of iodine glycerin was dipped into the affected area with a cotton swab for 3 times daily. Both groups were evaluated after 1 week of treatment. Results After treatment, the total effective rate of the treatment group was 98.28%, which was significantly higher than that of the control group (82.76%, P<0.05). After treatment, the pain relief time and ulcer healing time in the treatment group were significantly shorter than those in the control group (P<0.05). After treatment, SAS and VAS scores of patients in the two groups were significantly reduced (P<0.05), while QLQ-C30 score was significantly increased (P<0.05). After treatment, these scores were better in the treatment group than in the control group (P<0.05). After treatment, the serum levels of C-reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α) were significantly decreased, while the levels of interleukin-2 (IL-2) and epidermal growth factor (EGF) were significantly increased in both groups (P<0.05). After treatment, hs-CRP, IL-6 and TNF-α in the treatment group were lower than those in the control group, while IL-2 and EGF were higher than those in the control group (P<0.05). Conclusion Iodine Glycerol combined with Triamcinolone Acetonide Dental Paste in treatment of oral ulcer can significantly improve the clinical symptoms of patients, and can inhibit the inflammatory response, also can promote the healing of lesions, and is conducive to the improvement of anxiety state and life quality of patients, which has certain clinical application value.

R988.2

河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃項(xiàng)目（2018020488）