目的 研究棗仁安神膠囊聯(lián)合帕利哌酮緩釋片治療精神分裂癥的臨床療效。方法 選取2018年9月—2019年9月在天津市安定醫(yī)院治療的80例精神分裂癥患者。將患者隨機分為對照組和治療組，每組各40例。對照組患者口服帕利哌酮緩釋片，1片/次，1次/d；治療組患者在對照組基礎(chǔ)上口服棗仁安神膠囊，5粒/次，1次/d。兩組患者持續(xù)治療2個月。觀察兩組患者臨床療效，比較兩組的個人和社會功能量表（PSP）評分、陰性和陽性癥狀量表（PANSS）評分、生活質(zhì)量綜合評定量表（GQOLI-74）評分、血清白細胞介素-6（IL-6）和神經(jīng)營養(yǎng)因子3（NT-3）水平。結(jié)果 治療后，治療組總有效率（95.00%）顯著高于對照組（77.50%）（P<0.05）。治療后，兩組PSP評分、GQOLI-74評分明顯升高，PANSS評分明顯降低（P<0.05）；且治療組PSP評分、GQOLI-74評分明顯高于對照組，PANSS評分明顯低于對照組（P<0.05）。治療后，兩組血清IL-6水平顯著降低，血清NT-3水平明顯升高（P<0.05）；并且治療組改善較明顯（P<0.05）。結(jié)論 棗仁安神膠囊聯(lián)合帕利哌酮緩釋片治療精神分裂癥具有較好的療效，可改善臨床癥狀，降低血清炎性因子水平。

Objective To study the efficacy of Zaoren Anshen Capsules combined with Paliperidone Extended-Release Tablets in treatment of schizophrenia. Methods Patients (80 cases) with schizophrenia in Tianjin Anding Hospital from September 2018 to September 2019 were randomly divided into control and treatment groups, and each group had 40 cases. Patients in the control group were po administered with Paliperidone Extended-Release Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Zaoren Anshen Capsules on the basis of the control group, 5 grains/time, once daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacies were evaluated, and PSP score, PANSS score, GQOLI-74 score, the levels of IL-6 and NT-3 in two groups were compared. Results After treatment, the total effective rate of the treatment group (95.00%) was significantly higher than that of the control group (77.50%) (P<0.05). After treatment, PSP score and GQOLI-74 score of two groups were significantly increased, but PANSS score of two groups was significantly decreased (P<0.05); And the PSP score and the GQOLI-74 score of the treatment group were significantly higher than those of the control group, but the PANSS score of the treatment group was significantly lower than that of the control group (P<0.05). After treatment, the serum levels of IL-6 in two groups were significantly decreased, but the serum levels of NT-3 in two groups were significantly increased (P<0.05); And the indexes in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Zaoren Anshen Capsules combined with Paliperidone Extended-Release Tablets has clinical curative effect in treatment of schizophrenia, can improve the clinical symptoms, and reduce the serum level of inflammatory factors.

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