目的 研究蒲地藍(lán)消炎口服液聯(lián)合磷酸奧司他韋膠囊治療小兒病毒性肺炎的臨床療效。方法 選取2018年12月—2019年12月在河南科技大學(xué)第一附屬醫(yī)院治療的100例病毒性肺炎患兒為研究對(duì)象，將所有患兒隨機(jī)分為對(duì)照組和治療組，每組各50例。對(duì)照組口服磷酸奧司他韋膠囊，體質(zhì)量≤15 kg，30 mg/次，體質(zhì)量15～23 kg，45 mg/次，體質(zhì)量23～40 kg，60 mg/次，體質(zhì)量>40 kg，75 mg/次，2次/d。治療組在對(duì)照組基礎(chǔ)上口服蒲地藍(lán)消炎口服液，10 mL/次，3次/d。兩組患兒持續(xù)治療10 d。觀察兩組患兒臨床療效，比較兩組的臨床癥狀緩解時(shí)間、血清炎性細(xì)胞因子水平。結(jié)果 治療后，治療組總有效率（94.00%）顯著高于對(duì)照組（82.00%）（P<0.05）。治療后，治療組退熱時(shí)間、肺部啰音消失時(shí)間、咳嗽停止時(shí)間明顯短于對(duì)照組（P<0.05）。治療后，兩組血清C反應(yīng)蛋白（CRP）、白細(xì)胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）水平明顯降低（P<0.05）；且治療組血清CRP、IL-6、TNF-α水平降低較明顯（P<0.05）。結(jié)論 蒲地藍(lán)消炎口服液聯(lián)合磷酸奧司他韋膠囊治療小兒病毒性肺炎具有較好的療效，可以縮短臨床癥狀消失時(shí)間，降低血清炎性因子水平。

Objective To study the efficacy of Pudilan Xiaoyan Oral Liquid combined with Oseltamivir Phosphate Capsules in treatment of viral pneumonia in children. Methods Children (100 cases) with viral pneumonia in the First Affiliated Hospital of Henan University of Science and Technology from December 2018 to December 2019 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Oseltamivir Phosphate Capsules, body weight ≤ 15 kg, 30 mg/time, body weight 15-23 kg, 45 mg/time, body weight 23-40 kg, 60 mg/time, body weight > 40 kg, 75 mg/time, twice daily. Patients in the treatment group were po administered with Pudilan Xiaoyan Oral Liquid on the basis of the control group, 10 mL/time, three times daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacies were evaluated, and the remission time of clinical symptoms and the serum levels of inflammatory cytokines in two groups were compared. Results After treatment, the total effective rate of the treatment group (94.00%) was significantly higher than that of the control group (82.00%) (P<0.05). After treatment, the antipyretic time, pulmonary rales disappearance time, and cough stop time in the treatment group were significantly shorter than those in the control group (P<0.05). After treatment, the levels of CRP, IL-6 and TNF-α in two groups were significantly decreased (P<0.05), and the levels of CRP, IL-6, and TNF-α in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Pudilan Xiaoyan Oral Liquid combined with Oseltamivir Phosphate Capsules has clinical curative effect in treatment of viral pneumonia in children, can shorten the disappearance time of clinical symptoms, and reduce the serum level of inflammatory factors.

R974