柚皮素是一種具有多種生物活性的天然黃酮類化合物，具有抗炎、抗氧化、抗腫瘤等多種藥理作用。隨著現(xiàn)代分子生物技術和納米技術的進步，越來越多的研究對柚皮素進行納米化處理，并且在提高溶解度、改善吸收、提高靶向性、提高抗腫瘤活性、降低不良反應等方面取得了一定進展。通過查閱國內外文獻，對柚皮素納米制劑的藥理作用研究進行綜述，為其后續(xù)研發(fā)提供必要的思路和參考。

Naringenin is a kind of natural flavonoid compound with multiple biological activities and it has the pharmacological effects of anti-inflammatory, antioxidation, antitumor effects and so on. With the progress of modern molecular biotechnology and nanotechnology, more and more researches have been performed on naringenin nano crystallization, and some progress has been made in improving the solubility, absorption and targeting, enhancing anti-tumor activity, reducing adverse reactions. In this paper, we summarized pharmacology of naringenin nanoparticles on the basis of domestic and overseas literature, and provided necessary ideas and references for the future development.

R977

國家重點研發(fā)計劃中醫(yī)藥現(xiàn)代化研究重點專項（2018YFC1706700）；黑龍江省自然科學基金資助項目（H201472）