目的 探討杜仲顆粒聯(lián)合鹽酸拉貝洛爾注射液治療妊娠期高血壓的臨床療效。方法 選取2017年3月-2019年10月鄭州市婦幼保健院收治的80例妊娠期高血壓患者，根據(jù)隨機(jī)數(shù)字表法將所有患者分為對(duì)照組和治療組，每組各40例。對(duì)照組靜脈滴注鹽酸拉貝洛爾注射液，將100 mg鹽酸拉貝洛爾注射液溶于250 mL生理鹽水中，1次/d。治療組在對(duì)照組的基礎(chǔ)上溫水沖服杜仲顆粒，5 g/次，2次/d。兩組患者連續(xù)治療2周。觀察兩組臨床療效，比較兩組的收縮壓、舒張壓、血流動(dòng)力學(xué)指標(biāo)、不良妊娠結(jié)局。結(jié)果 治療后，治療組的總有效率為87.50%，高于對(duì)照組的65.00%，組間比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組收縮壓、舒張壓較治療前降低（P<0.05）；且治療組收縮壓、舒張壓較對(duì)照組低（P<0.05）。治療后，兩組心臟指數(shù)較治療前升高，外周阻力較治療前降低（P<0.05）；治療后治療組心臟指數(shù)較對(duì)照組高，外周阻力較對(duì)照組低（P<0.05）。治療后，治療組患者的不良妊娠結(jié)局發(fā)生率為12.50%，低于對(duì)照組患者的32.50%（P<0.05）結(jié)論 杜仲顆粒聯(lián)合鹽酸拉貝洛爾注射液治療妊娠期高血壓具有較好的臨床療效，可有效改善患者血流動(dòng)力學(xué)，降低血壓和不良妊娠結(jié)局發(fā)生率，且安全性較好。

Objective To investigate clinical efficacy of Duzhong Granules combined with Labetalol Hydrochloride Injection in treatment of hypertensive disorder complicating pregnancy. Methods Patients (80 cases) with hypertensive disorder complicating pregnancy in Women & Infants Hospital of Zhengzhou from March 2017 to October 2019 were randomly divided into control and treatment groups, and each group had 40 cases. Patients in the control group were iv administered with Labetalol Hydrochloride Injection, 100 mg added into normal saline 250 mL, once daily. Patients in the treatment group were po administered with Duzhong Granules on the basis of the control group, 5 g/time, twice daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and systolic blood pressure, diastolic blood pressure, hemodynamic indicators, and adverse pregnancy outcomes in two groups were compared. Results After treatment, the total effective rate of the treatment group was 87.50%, which was higher than 65.00% of the control group (P<0.05). After treatment, the systolic blood pressure and diastolic blood pressure of two groups were decreased (P<0.05), and these indexes of the treatment group were lower than those of the control group (P<0.05). After treatment, the cardiac index of two groups was increased, but the peripheral resistance was decreased (P<0.05). After treatment, the cardiac index of the treatment group was higher than that of the control group, but the peripheral resistance was lower than that of the control group (P<0.05). After treatment, the incidence of adverse pregnancy outcomes in the treatment group was 12.50%, which was lower than 32.50% in the control group (P<0.05). Conclusion Duzhong Granules combined with Labetalol Hydrochloride Injection has clinical effect in treatment of hypertensive disorder complicating pregnancy, can effectively improve the hemodynamics, reduce the blood pressure and the incidence of adverse pregnancy outcomes, with good safety.

R984

河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃項(xiàng)目（2018020716）