目的 探討克霉唑陰道栓聯(lián)合氟康唑治療霉菌性陰道炎的臨床療效及安全性。方法 ：選擇2019年3月-2020年3月收治的霉菌性陰道炎患者108例，隨機(jī)分為對(duì)照組（54例）和治療組（54例）。對(duì)照組口服氟康唑膠囊，首劑量0.4 g/次，次日0.2 g/次，1次/d。治療組患者在對(duì)照組的基礎(chǔ)上睡前陰道深處給予克霉唑陰道栓，月經(jīng)后開始治療，1次/d。兩組患者連續(xù)治療21 d。觀察兩組患者臨床療效，同時(shí)比較治療前后兩組患者臨床癥狀改善情況、復(fù)發(fā)率和生存質(zhì)量。結(jié)果 ：治療后，對(duì)照組和治療臨床有效率為83.33%和96.30%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組腰腹疼痛、尿頻尿痛和外陰瘙癢紅腫消失時(shí)間及白帶恢復(fù)正常時(shí)間明顯早于對(duì)照組（P<0.05）。治療后，對(duì)照組復(fù)發(fā)率高于治療組（P<0.05）。治療后，治療組精神狀態(tài)、情感狀態(tài)、社會(huì)功能和生理機(jī)能評(píng)分明顯好于對(duì)照組（P<0.05）。結(jié)論 克霉唑陰道栓聯(lián)合氟康唑治療霉菌性陰道炎效果顯著，提高生存質(zhì)量，改善患者臨床癥狀和降低臨床復(fù)發(fā)率，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical efficacy and safety of Clotriazole Vaginal Suppository combined with fluconazole in treatment of mycotic vaginitis. Methods Patients (108 cases) with mycotic vaginitis in Central Hospital of Shangqiu from March 2019 to March 2020 were randomly divided into control (54 cases) and treatment (54 cases) groups. Patients in the control group were po administered with Fluconazole Capsules, the initial dose was 0.4 g/time, then 0.2 g/time for the next day. Patients in the treatment group were deep vagina given administered with Clotriazole Vaginal Suppository on the basis of the control group after menstruation, once daily. Patients in two groups were treated for 21 d. After treatment, the clinical efficacy was evaluated, and the improvement of clinical symptom, the recurrence rate, and the survival quality in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 83.33% and 96.30% respectively, and there were differences between two groups (P<0.05). After treatment, the disappearance time of waist and abdomen pain, frequent micturition, pruritus and swelling of vulva and the recovery time of leucorrhea in the treatment group were significantly earlier than those in the control group (P<0.05). After treatment, the recurrence rate of the control group was higher than that of the treatment group (P<0.05). After treatment, the mental state, emotional state, social function and physiological function of the treatment group were significantly better than those of the control group (P<0.05). Conclusion The clinical effect of Clotriazole Vaginal Suppository combined with fluconazole in treatment of mycotic vaginitis is remarkable, which can improve the life quality, improve the clinical symptoms and reduce the recurrence rate, and has a certain clinical application value.

R984