隨著抗菌藥物使用的增加，腸桿菌科細(xì)菌耐藥的情況越發(fā)嚴(yán)重，可供選擇的抗菌藥物將越來越少。天然藥物因其作用范圍廣、毒副作用較小在抗感染研究中備受關(guān)注，而天然藥物單體即是其發(fā)揮藥理學(xué)作用的物質(zhì)基礎(chǔ)。就近年來天然藥物單體對(duì)腸桿菌科細(xì)菌的作用及其機(jī)制進(jìn)行綜述，為抗菌藥物的篩選和開發(fā)提供參考。

With the increase of antimicrobial drugs use, the resistance of Enterobacteriaceae is becoming more and more serious, and the available antimicrobial drugs will be less and less. Due to its wide range of action, natural drugs have little toxic side effects. Nowadays, it has attracted much attention in anti-infection research, and natural drug active component is the material basis for its pharmacological action. In this paper, the effect and mechanism of natural drug active components on Enterobacteriaceae in recent years were reviewed, so as to provide reference for the screening and development of antibacterial drugs.

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國家自然科學(xué)基金面上項(xiàng)目（81670637）；廣州市基礎(chǔ)研究計(jì)劃項(xiàng)目（202002030419）；廣州市加速康復(fù)腹部外科重點(diǎn)實(shí)驗(yàn)室（201905010004）