褪黑素是存在于生物內(nèi)的重要激素，具有抗氧化、改善睡眠、調(diào)節(jié)免疫等多種生理作用，作為保健食品原料用于改善睡眠。近年來有研究表明褪黑素有一定的降血糖作用，其機(jī)制可能與改善胰島素抵抗、保護(hù)胰島β細(xì)胞、調(diào)節(jié)下丘腦-垂體-腎上腺軸等作用有關(guān)。對(duì)褪黑素的降血糖作用及其機(jī)制研究進(jìn)行綜述，以期褪黑素及促進(jìn)內(nèi)源性褪黑素、受體激動(dòng)相關(guān)的活性物質(zhì)作為潛在的降血糖藥物用于糖尿病患者提供參考。

Melatonin is an important hormone secreted by the human body. It has the functions of delaying aging, improving sleep, and regulating immunity, etc. As a raw material for health food, melatonin is used to improve sleep. In recent years, studies have found that melatonin has a certain hypoglycemic effect, and its mechanism may be related to improving insulin resistance, protecting pancreatic β-cells, and regulating the hypothalamus-pituitary-adrenal axis. In this paper, the hypoglycemic effects and mechanisms of melatonin are reviewed in order to provide reference for potential hypoglycemic agents such as melatonin, active substances that promote endogenous melatonin and receptor activation.

R285